The effect of curcumin on rheumatoid arthritis

The effect of curcumin-piperine supplementation on anthropometric indices and clinical signs in patients with rheumatoid arthritis A double-blind clinical trial study

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20120701010149N3

Enrollment

Registered

2021-05-01

Start date

2021-05-04

Completion date

Unknown

Last updated

2021-05-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Rheumatoid Arthritis. Rheumatoid arthritis with rheumatoid factor

Interventions

Intervention 1: Intervention group: Patients receiving one 500 mg capsule per day of curcumin-piperine (500 mg curcumin-5 mg piperine) per day for 12 weeks (30 patients). Intervention 2: Control group

Eligibility

Sex/Gender

All

Age

20 Years to 60 Years

Inclusion criteria

Inclusion criteria: Willingness to participate in the study Age 20-60 years Rheumatoid arthritis according to the rheumatologist according to the American College of Rheumatology 2010, the disease activity score is higher than 1/5 and the total soft joint count (TJC) and swollen joint count (SJC) is higher than 8.

Exclusion criteria

Exclusion criteria: Pregnancy and lactation Smoking Heart, lung and kidney disease, hepatitis, cirrhosis, biliary and immune system disorders, hypertension, diabetes, hypothyroidism, Cushing's syndrome

Design outcomes

Primary

Measure	Time frame
Symptoms. Timepoint: Beginning and end of the study. Method of measurement: Symptoms will be measured using the Disease Activity Score of 28 joints (DAS - 28). Soft joint count (TJC) and swollen joint count (SJC) are determined by a rheumatologist.	—

Countries

Iran (Islamic Republic of)

Contacts

Public Contactpeiman motaghi

Esfahan University of Medical Sciences

motaghi@med.mui.ac.ir+98 31 3620 2020

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026