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Effect of Dexamethasone in epidural anesthesia with Bupivacaine

Effectiveness of adding Dexamethasone to epidural Bupivacaine on the onset of anesthesia and duration of perioperative analgesia in unilateral inguinal herniorrhaphy.

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT2012062910137N1
Enrollment
44
Registered
2012-07-21
Start date
2012-07-22
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Inguinal hernia. Unilateral or unspecified inguinal hernia, without obstruction or gangrene

Interventions

Intervention 1: Dexamethasone 8 mg, epidural injection, single dose. Intervention 2: Sterile water, 2 ml, Epidural injection, single dose.
Treatment - Drugs
Placebo
Dexamethasone 8 mg, epidural injection, single dose.
Sterile water, 2 ml, Epidural injection, single dose

Sponsors

Kashan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
30 Years to 70 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Patients aged 30-70 years; ASA class I-II; Candidates for unilateral inguinal herniorrhaphy. Exclusion criteria: Complicated inguinal hernia (Incarcerated, strangulated and so on); History of peptic ulcer disease; Any contraindication for epidural anesthesia (beck fusion, coagulopathy, local infection, inability to give appropriate position); Failure to achieve epidural analgesia; Obese and diabetic patients, and patients who had received corticosteroids or immunosuppressive drugs in the last 6 months, or if they had contraindication to corticosteroids; Any contraindication for corticosteroid administration; Patient refusal for epidural anesthesia.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Onset of anesthesia. Timepoint: Every 30 seconds, after intervention. Method of measurement: Pinprick test.;Duration of analgesia. Timepoint: Every 1 minute, after intervention. Method of measurement: Pain perception by the patient.;Pain intensity. Timepoint: Just after starting pain. Method of measurement: Visual analogue scale.

Secondary

MeasureTime frame
Nausea. Timepoint: In 1st hour after intervention. Method of measurement: Patient observation.;Vomiting. Timepoint: In 1st hour after intervention. Method of measurement: Patient observation.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactNabiollah Heydarian

Kashan University of Medical Sciences

drheydarian@yahoo.com+98 36 1555 2999

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 27, 2026