Acute Opioids Toxicity. Mental and behavioural disorders due to use of opioids
Conditions
Interventions
After emergency management (if needed) the patients in intervention group will take a single dose of 50mg naltrexone orally . During the hospital stay, the prevalence of respiratory depression or resp
The patients in control group after emergency management (if needed) will take a placebo drug. These patient during hospital admission will monitor regarding to respiratory depression or arrest and lo
Treatment - Drugs
Intervention group
Control group
Sponsors
Loghman-Hakim Toxicological Reserch Center dependent to Shahid-Beheshti University
Eligibility
Sex/Gender
All
Age
14 Years to 100 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: The acutely methadone-poisoned patients ;opioid non-dependent patients; Exclusion criteria: The addicted patients (Opioid-dependent patients); Active liver disease; Acute methadone poisoning with development of complications (aspiration pneumonia, brain trauma, and cardiogenic or non-cardiogenic pulmonary edema); History of acute coronory syndrome in last 3 weeks
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Oxygenation (Arterial Blood Oxygen Saturation in Percent). Timepoint: Continuously up to 48 hours. Method of measurement: Pulseoxymetery.;Ventilation status. Timepoint: every 6 hours up to 48 hours. Method of measurement: Arterial or venous blood gas.;Hospital Stay. Timepoint: Hours. Method of measurement: Based on registration of time and date on medical file.;Acute Complications. Timepoint: Up to 48 hours. Method of measurement: Physical Examination, inspection and paraclinic data.;Respiratory rate per minute. Timepoint: hour to hour up to 48 hours. Method of measurement: physical examination and inspection. | — |
Secondary
| Measure | Time frame |
|---|---|
| Level of Consciousness. Timepoint: hour to hour Up to 48 hours. Method of measurement: Physical Examination and assessment of neurologic system.;Need to naloxone. Timepoint: During 48 hrs admission. Method of measurement: Dose of Naloxone Received (mg). | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactHosein Hassanian-Moghaddam
Shahid Beheshti University of Medical Sciences
Outcome results
None listed