Toxic alcohols. Toxic effect of methanol
Conditions
Interventions
Intervention group: iHV. The concept of isocapnic hyperventilation (iHV) allows the person to hyperventilate while keeping the CO2 within normal limits at the same time. The ClearMate (Thornhill Resea
Sponsors
Shahid Beheshti University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Adult patients, men & women diagnosed with methanol poisoning Serum methanol = 50mg/dL pH = 7.0, correctable by bicarbonate infusion no visual disturbances
Exclusion criteria
Exclusion criteria: Acidosis requiring haemodialysis Comatose patients
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in methanol elimination kinetics (half-life and estimated clearance) when iHV is utilized. Timepoint: Hourly before intervention, and 1-2 hourly post intervention till 24 hours. Method of measurement: Measuring serum/urine methanol, formate. | — |
Secondary
| Measure | Time frame |
|---|---|
| Score of iHV machine tolerability. Timepoint: Hourly. Method of measurement: Qualitative interview.;Score of feasibility of iHV machine. Timepoint: Hourly. Method of measurement: Likert's scale.;Implementation of fomepizole in Iran. Timepoint: End of trial. Method of measurement: Likert's scale.;Length of ICU- and hospital stay during treatment with iHV. Timepoint: End of trial. Method of measurement: Time frame of hospital stay.;Death. Timepoint: End of trial. Method of measurement: Yes or No.;Need for haemodialysis. Timepoint: hourly. Method of measurement: Yes or No.;Adverse Events. Timepoint: hourly. Method of measurement: Yes or No. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactHosssein Hassanian-Moghaddam
Shahid Beheshti University of Medical Sciences
Outcome results
None listed