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Nebulized naloxone in methadone poisoning

The effect of nebulized naloxone in comparison with intravenous naloxone in patients with methadone overdose, a randomized clinical trial study

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20120629010133N4
Enrollment
60
Registered
2022-07-07
Start date
2022-07-16
Completion date
Unknown
Last updated
2022-08-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Opioid, Methadone, Poisoning, naloxone infusion, Nebulized naloxone. Poisoning by, adverse effect of and underdosing of methadone

Interventions

Intervention 1: Intervention group: naloxone administration by jet nebulizer, using 2/3 of i.v. naloxone in emergency department to avoid re-narcosis. Intervention 2: Control group: naloxone administr

Sponsors

Shahid Beheshti University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Methadone Overdose >18 and <60 Response to naloxone Opioid dependency Spontaneous respiration

Exclusion criteria

Exclusion criteria: No consent to participate nasal congestion Current catching cold Apnea Intubation

Design outcomes

Primary

MeasureTime frame
O2 Saturation. Timepoint: On admission, then each hour till 6 hours, then each 3 hours. Method of measurement: Pulse oxymetery.;PCo2. Timepoint: On admission, then each hour till 6 hours, then each 3 hours. Method of measurement: Blood gasometery.;Level of consiousness using Glasgow Coma Scale. Timepoint: On admission, then each hour till 6 hours, then each 3 hours. Method of measurement: Physical Examination.

Secondary

MeasureTime frame
Withdrawal Syndrome using COWS scale. Timepoint: Each 3 hours. Method of measurement: Examination.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAbbas Edalatkhah

Shahid Beheshti University of Medical Sciences

abbas_edalatkhah@yahoo.com+98 21 5540 9534

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026