Benzodiazepine poisoning. Poisoning by, adverse effect of and underdosing of hydantoin derivatives
Conditions
Interventions
Intervention 1: Intervention group: Administration of flumazenil drip (initial dose of 200 micro per hour and its adjustment based on patient's situations) followed by its tapering. Intervention 2: Co
Sponsors
NIMAD (National Institute for Medical Research Development)
Eligibility
Sex/Gender
All
Age
12 Years to No maximum
Inclusion criteria
Inclusion criteria: Severely benzodiazepine-poisoned patients (in need for intubation and mechanical ventilation) with otherwise normal vital signs
Exclusion criteria
Exclusion criteria: Abnormal vital signs on presentation, history of seizure, history of ingestion or use of any drug/medication that can predispose the patient to seizure, history of head trauma, possible brain edema and increased intracranial pressure, history of hypoxemia
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mortality-. Timepoint: 7 days after admission. Method of measurement: Observation and questionnaire recording.;Complications during hospitalization. Timepoint: 7 days after admission. Method of measurement: Observation and questionnaire recording.;Intubation. Timepoint: 7 days after admission. Method of measurement: Observation and questionnaire recording. | — |
Secondary
| Measure | Time frame |
|---|---|
| Hospitalization period. Timepoint: At discharge or death. Method of measurement: Observation and questionnaire recording. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactHossein Hassanian-Moghaddam
Shahid Beheshti University of Medical Sciences
Outcome results
None listed