Effectiveness of probiotics yoghurt on treatment and recurrence of bacterial vaginosis

Effectiveness of probiotics yoghurt as a complementary method on treatment and recurrence of bacterial vaginosis: a randomized controlled trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT201206243706N13

Enrollment

140

Registered

2012-07-14

Start date

2012-07-22

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bacterial Vaginosis. other inflammation of vagina and vulva

Interventions

Intervention 1: Intervention group( metronidazol tablet + probiotic yogurt) at first 7 days metronidazol(500 mg Twice a day) then probiotic yogurtdaily for 2 month. Intervention 2: Control group( me

Treatment - Drugs

Placebo

Intervention group( metronidazol tablet + probiotic yogurt) at first 7 days metronidazol(500 mg Twice a day) then probiotic yogurtdaily for 2 month.

Control group( metronidazol tablet + Pasteurized yogurt)at first 7 days metronidazol(500 mg Twice a day) then Pasteurized yogurt daily for 2 month.

Eligibility

Sex/Gender

Female

Age

15 Years to 49 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: 1- Married, non pregnant, non lactatating women aged 49-15 years 2-diagnosis of bacterial vaginosis by Amsel and Nugent Criteria). 3 - no abnormal vaginal bleeding. 4 - no probable intervening situations with the test results (menstruation at time of smear, having sex during last 48 houres, use of douch during last 48 houres) 5 -giving informeed consent to participate the study and be able to present at the clinic during next 24 houres, once every 2 weeks for next 2 month (to get the yoghurts), and also after 3 months, and after 6 months for assessments. Exclusion criteria: 1 - use of antibiotics in last 2 weeks. 2 - use of vaginal drugs in last 30 days. 3 - suffering from HIV. 4 - suffering from heart disease and kidney failure. 5 - Having surgery on the colon. 6 – smoking. 7 - Starting to use IUD in the last month or deciding to Insert IUD in following 3 months. 8 - useing immunosuppressive drugs.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Microbiological cure. Timepoint: 10+-2 days after starting treatment. Method of measurement: Microbiologocal cure as assessed by Amsel criteria and Nugent score.;Recurrence of bacterial vaginosis. Timepoint: 90 and 180 +- 7 days after starting treatment. Method of measurement: Amsel criteria and Nugent score.	—

Secondary

Measure	Time frame
Clinical cure. Timepoint: 10 +- 3 days and 90 and 180 +-7 days after starting treatment. Method of measurement: Patient and clinician reports.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSomayeh Ziyadi

Nursing & Midwifery faculty

s.ziyadi@yahoo.com00

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026