Comparison of the Effect of Norepinephrine and Ephedrine Infusion on Stabilizing Blood Pressure and Hemodynamics during Cesarean Section under Spinal Anesthesia

Comparison of the Effect of Norepinephrine and Ephedrine Infusion on Stabilizing Blood Pressure and Hemodynamics of Mother Candidates for Cesarean Section under Spinal Anesthesia

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20120624010102N4

Enrollment

100

Registered

2024-09-17

Start date

2024-08-22

Completion date

Unknown

Last updated

2025-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pregnancy, candidate for caesarean section, under spinal anesthesia. Other complications of spinal and epidural anesthesia during pregnancy

Interventions

Intervention 1: Intervention group: receiving ephedrine as an infusion of 1 mg/kg/minute. Intervention 2: Intervention group: receiving norepinephrine as an infusion of 0.05 µg/kg/min.

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: All Pregnant Mothers Cesarian Candidate Under Spinal Anesthesia ASA Class of One and Two

Exclusion criteria

Exclusion criteria: History of any underlying disease, including heart disease, kidney disease, diabetes, etc.

Design outcomes

Primary

Measure	Time frame
Mother Heart Rate. Timepoint: At the beginning and during surgery, every three minutes until the placenta is removed. Method of measurement: Monitoring Device.;Fetus Heart Rate. Timepoint: At the beginning and during surgery, every three minutes until the placenta is removed. Method of measurement: Monitoring Device.;Maternal Mean Arterial Pressure. Timepoint: At the beginning and during surgery, every three minutes until the placenta is removed. Method of measurement: Monitoring Device.;Maternal Blood Oxygen Saturation. Timepoint: At the beginning and during surgery, every three minutes until the placenta is removed. Method of measurement: Monitoring Device.	—

Measure

Time frame

Mother Heart Rate. Timepoint: At the beginning and during surgery, every three minutes until the placenta is removed. Method of measurement: Monitoring Device.;Fetus Heart Rate. Timepoint: At the beginning and during surgery, every three minutes until the placenta is removed. Method of measurement: Monitoring Device.;Maternal Mean Arterial Pressure. Timepoint: At the beginning and during surgery, every three minutes until the placenta is removed. Method of measurement: Monitoring Device.;Maternal Blood Oxygen Saturation. Timepoint: At the beginning and during surgery, every three minutes until the placenta is removed. Method of measurement: Monitoring Device.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactSanaz Rajabloo

Tehran University of Medical Sciences

sanaz.rj@gmail.com+98 21 6634 8500

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026