effect of duloxetine on post operative pain

Effect of Duloxetine administeration on postoperative pain after abdominal hysterectomy compared to the placebo

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20120624010102N2

Enrollment

Registered

2019-12-10

Start date

2020-01-20

Completion date

Unknown

Last updated

2019-12-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

control of acute post operative pain.

Interventions

Intervention 1: Intervention group: Oral duloxetine capsule 60 mg (Kharazmi Pharmacy) 2 hours before surgery(SNRI). Intervention 2: Control group: Placebo 2 hours before surgery.

Eligibility

Sex/Gender

Female

Age

35 Years to 65 Years

Inclusion criteria

Inclusion criteria: Female age 35-65 Elective total abdominal hysterectomy ASA class 1 & 2

Exclusion criteria

Exclusion criteria: patient refusal Any alergic history with Duloxetine or other SNRIs surgery longer than 3 hours Postoperative cancer diagnosis or any other pelvic pathology during the operation Need additional surgery Any other incision than Pfannenstiel

Design outcomes

Primary

Measure	Time frame
Pain. Timepoint: 30 min ,1 , 2 , 6 ,12 hours after surgery. Method of measurement: VAS score.	—

Secondary

Measure	Time frame
Nausea and vomiting. Timepoint: 0 to 12 hours postoperative. Method of measurement: Asking.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFahime Zamiri

Tehran University of Medical Sciences

fahimezamiri139431@gmail.com+98 21 8899 5767

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026