Preterm labor and delivery. Preterm spontaneous labor with term delivery
Conditions
Interventions
Intervention 1: Intravenous loading dose infusion was 4gr magnesium sulfate (20%) during 30 minutes, followed by a maintenance dose of 2 gr/hr until stopping or reducing uterine contractions.
(magnes
until a maximum dose of 40mg for one hour. Depending on tocolytic effects of nifedipine that we have used during one hour, we used a minimal dose of 60 mg every day. After 3 days, the dose would be de
Treatment - Drugs
Intravenous loading dose infusion was 4gr magnesium sulfate (20%) during 30 minutes, followed by a maintenance dose of 2 gr/hr until stopping or reducing uterine contractions.
(magnesium sulfate hep
We have used one capsule nifedipine (10 mg sublingual from Dana pharmaceutical company, Iran and its Generic name was Nifi-Gel). If uterine contractions persisted, we would use another capsule every 1
Sponsors
Vice Chancellor for Research, Guilan University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
15 Years to 45 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: Singleton pregnancy, 24 to 37 weeks of gestation, signs of preterm labor. Exclusion criteria : premature rupture of membrane, cervical dilatation > 4 cm, gestational age 37 weeks, chorioamnionitis, vaginal bleeding, multiple pregnancy, previous cesarean section, previous uterus surgery, maternal or fetal indications for termination of pregnancy such as preeclampsia, fetal distress, fetal growth abnormalities and decreased blood pressure.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Delaying delivery up to 48 hours. Timepoint: Every 15 minutes until stopping of uterine contractions. Method of measurement: Abdominal palpation of uterus. | — |
Secondary
| Measure | Time frame |
|---|---|
| Cervical dilatation. Timepoint: Every 2 hours until stopping of uterine contractions. Method of measurement: Vaginal examination.;Uterine contractions. Timepoint: Every 15 minutes until stopping of uterine contractions. Method of measurement: Abdominal palpation of uterus.;Cervical effacement. Timepoint: Every 2 hours until stopping of uterine contractions. Method of measurement: Vaginal examination.;Fetal complications. Timepoint: During drug administration. Method of measurement: Physician assessment.;Maternal complications. Timepoint: During drug administration. Method of measurement: Physician assessment. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr.Roya Faraji Darkhaneh
Guilan University of Medical Sciences
Outcome results
None listed