Labor induction in term pregnant women of with oral misoprostol or oxytocin

Induction and augmentation of labor with oral misoprostol versus oxytocin in term pregnancy: randomized controlled trial

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

IRCT

Registry ID

IRCT2012061910068N1

Enrollment

285

Registered

2012-07-05

Start date

2008-01-01

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

labor induction. Pregnancy with abortive outcome

Interventions

Intervention 1: In the oxytocin group, infusion rate of 2 mIU/min was prescribed for induction and gradually increased by 2 mIU/min every 15 minutes to a maximum dose of 36 mIU/min. In presence of any

Treatment - Drugs

In the oxytocin group, infusion rate of 2 mIU/min was prescribed for induction and gradually increased by 2 mIU/min every 15 minutes to a maximum dose of 36 mIU/min. In presence of any tachysystole (5

Initiation of labor induction was the time at which the first misoprostol dose was administered (group 1) or the oxytocin infusion was started (group 2). In the misoprostol group, a tablet of 200 µg

Eligibility

Sex/Gender

Female

Age

14 Years to 40 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: term pregnant women whom were candidate for vaginal delivery; gestational age of 38 to 42 weeks; birth weight of maximally 4000 grams; normal fetal heart rate; cephalic presentation; lack of uterine contractures; single pregnancy and Bishop Score of six and less. The exclusion criteria were lack of satisfaction for incorporation in the study; having a positive history of uterine surgery including cesarean; intrauterine growth retardation (IUGR); oligohydramnios; placenta previa; umbilical cord prolapse; active herpes infection; symptoms of chorioamnionitis; hepatic or renal disease; non-reactive contraindications for prostaglandins use; contraindications for labor induction and idiopathic vaginal bleeding.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
The time from induction to delivery. Timepoint: 12, 18, and 24 hours during labor. Method of measurement: Data recording.;The time from induction to the beginning of the active phase. Timepoint: 12, 18, and 24 hours during labor. Method of measurement: Data recording.;Mode of delivery. Timepoint: 12, 18, and 24 hours during labor. Method of measurement: Data recording.	—

Secondary

Measure	Time frame
Maternal complications. Timepoint: Peri labor phase. Method of measurement: Data record.;Fetal and neonatal status. Timepoint: Peri labor phase. Method of measurement: Data record.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAida Moeini

Department of Obstetrics and Gynecology, Shahid Beheshti University of Medical Science

a.moeini64@gmail.com+98 21 2271 8000

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Mar 24, 2026