Evaluation of Vitamin C Administration Effect on Gene Expression of Proinflamatory Cytokines

Evaluation of Gene Expression pattern of IL1B and IL10 Cytokines following vitamin C Administration Among Brain-Dead Liver Donors

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2012061410031N1

Enrollment

Registered

2013-04-21

Start date

2012-08-26

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Unstable condition of bran death patient. liver transplant status

Interventions

Intervention 1: Intervention group:Vitamin C administration with initial dose of 100 mg/ kg and maintenance dose of 100 mg/ kg/6h until end of donor transplant. Intervention 2: Control group: There is

Treatment - Drugs

Intervention group:Vitamin C administration with initial dose of 100 mg/ kg and maintenance dose of 100 mg/ kg/6h until end of donor transplant.

Control group: There is no intervention in the control group.

Eligibility

Sex/Gender

All

Age

10 Years to 60 Years

Inclusion criteria

Inclusion criteria: Inclusion criterion: 10-60 y/o confirmed deadbrain case who has the UNOS standard criteria. Exclusion criterion: the deadbrain patient who had a cardiac arrest.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
IL10. Timepoint: Six hours before the operation of deadbrain donor (in intervention group before starting to intervention)- Immediately after laparotomy- Immediately before clamping of Aorta. Method of measurement: Evaluation of Gene Expression pattern of IL10 Cytokine by Real time PCR.;IL1B. Timepoint: Six hours before the operation of deadbrain donor (in intervention group before starting to intervention)- Immediately after laparotomy- Immediately before clamping of Aorta. Method of measurement: Evaluation of Gene Expression pattern of IL1B Cytokine by Real time PCR.	—

Measure

Time frame

IL10. Timepoint: Six hours before the operation of deadbrain donor (in intervention group before starting to intervention)- Immediately after laparotomy- Immediately before clamping of Aorta. Method of measurement: Evaluation of Gene Expression pattern of IL10 Cytokine by Real time PCR.;IL1B. Timepoint: Six hours before the operation of deadbrain donor (in intervention group before starting to intervention)- Immediately after laparotomy- Immediately before clamping of Aorta. Method of measurement: Evaluation of Gene Expression pattern of IL1B Cytokine by Real time PCR.

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Secondary

Measure	Time frame
The serum level of AST. Timepoint: 1, 3 and 10 days after donor transplant. Method of measurement: Measurement of the relevant factor in the blood.;The serum level of Bilirobin -Total. Timepoint: 1, 3 and 10 days after donor transplant. Method of measurement: Measurement of the relevant factor in the blood.;The serum level of ALT. Timepoint: 1, 3 and 10 days after donor transplant. Method of measurement: Measurement of the relevant factor in the blood.	—

Measure

Time frame

The serum level of AST. Timepoint: 1, 3 and 10 days after donor transplant. Method of measurement: Measurement of the relevant factor in the blood.;The serum level of Bilirobin -Total. Timepoint: 1, 3 and 10 days after donor transplant. Method of measurement: Measurement of the relevant factor in the blood.;The serum level of ALT. Timepoint: 1, 3 and 10 days after donor transplant. Method of measurement: Measurement of the relevant factor in the blood.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Mohamad Bagher Khosravi

Namazi Hospital, Shiraz University of Medical Sciences

khosravimb@sums.ac.ir+98 71 1612 5157

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026