feeding intolerance. Underfeeding of newborn
Conditions
Interventions
Intervention 1: in intervention group: erythromycin syrup, 20 mg/kg/ day, every 6 hours. for 8 days
in control group: distilled water, 20 cc/kg/day, every 6 hours, for 8 days. Intervention 2: Control
Treatment - Drugs
in intervention group: erythromycin syrup, 20 mg/kg/ day, every 6 hours. for 8 days
in control group: distilled water, 20 cc/kg/day, every 6 hours, for 8 days
Control group: distilled water equal volume of erythromycin for 8 days
Sponsors
Esfahan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
14 Days to 1 Months
Inclusion criteria
Inclusion criteria: premature infants weight lower than 1800 grams feeding volume less than 75 cc/kg/ day in the 14th day after birth frequent lavage (i.e. => 2 times lavage; >50% of milk volume) parents willingness
Exclusion criteria
Exclusion criteria: presence of sepsis gastrointestinal anomalies cyanotic heart disease history of operation on gastrointestinal system in the first 14 days after birth consumption of medication effective in erythromycin metabolism in the same time incidence of arrhythmia or prolonged QT interval parents unwillingness
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time duration to reach to 75, 110 and 150 cc/kg/ day feeding volume. Timepoint: daily, during intervention. Method of measurement: observation. | — |
Secondary
| Measure | Time frame |
|---|---|
| Time duration of oxygen dependency. Timepoint: during intervention. Method of measurement: observation.;Time duration of hospitalization. Timepoint: during intervention. Method of measurement: observation.;Sepsis incidence. Timepoint: during intervention. Method of measurement: physical examination.;Necrotizing enterocolitis incidence. Timepoint: during intervention. Method of measurement: physical examination. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAmir-mohammad Armanian
Esfahan University of Medical Sciences
Outcome results
None listed