Cholecystitis. Cholecystitis
Conditions
Interventions
Intervention 1: Acetazolamide tablet before induction of anesthesia & placebo of paracetamol at the end of surgery. Intervention 2: Placebo tablet of acetazolamide before induction of anesthesia & Pla
Treatment - Drugs
Acetazolamide tablet before induction of anesthesia & placebo of paracetamol at the end of surgery
Placebo tablet of acetazolamide before induction of anesthesia & Placebo Paracetamol at the end of surgery
Paracetamol infusion at the end of surgery & placebo tablet of acetazolamide before induction of anesthesia
Sponsors
Mashhad University of Medical Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Inclusion Criteria 1- Patients candidates for laparoscopic cholecystectomy Excusion Criteria 1- Patients with pain disorder 2- Intraoperative complications such as cystic artery bleeding, leakage of bile into the peritoneal cavity 3- Postoperative complications such as bile duct injury, bile leakage, or biliary ascites. 4- Consumption of any narcotics and analgesics within 1 or 2 days before surgery. 5- Narcotics addicts 6- Contraindications to acetaminophen and acetasolamide, also lactose and starch (as components of the placebo) 7- Presence of inflammation, adhesions and excessive dissection which may prolong the operative time for more than 1 hours 8- The need for drain insertion
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain intensity. Timepoint: Immediately before and after surgery, after return of consciousness, at the time of stay in post-operative care unit, during 24 hours stay in the ward and at the time of discharge. Method of measurement: Visual Analog Scale (VAS).;Pain location. Timepoint: Immediately before and after surgery, after return of consciousness, at the time of stay in post-operative care unit, during 24 hours stay in the ward and at the time of discharge. Method of measurement: Objectively. | — |
Secondary
| Measure | Time frame |
|---|---|
| Analgesic consumption. Timepoint: Immediately before and/or after surgery and/or after return of consciousness and/or at the time of stay in post-operative care unit and/or during 24 hours stay in the ward and/or at the time of discharge. Method of measurement: mg. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Arash Peivandi Yazdi
Mashhad University of Medical Sciences
Outcome results
None listed