status epilepticus. Status epilepticus
Conditions
Interventions
Intervention 1: Intervention: valproate Loading: 20mg/kg, then 20-30mg/kg/24 hr. Intervention 2: Control: midazolam Loading: 0/15mg/kg, then 1-6µg/kg/min.
Treatment - Drugs
Intervention: valproate Loading: 20mg/kg, then 20-30mg/kg/24 hr
Control: midazolam Loading: 0/15mg/kg, then 1-6µg/kg/min
Sponsors
Research Center of Mazandaran University of Medical Sciences and Health Services
Eligibility
Sex/Gender
All
Age
3 Months to 14 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: Minimum age 3 month and maximum 14 years old ; Absence of renal or hepatic disfunction, shock, atrial or ventricular block ; No drug history of valproate or midazolam therapy in control of status epilepticus ; Normal range of CBC, BS,Ca, Na, K, BUN, Cr, SGOT, SGPT at beginning of treatment ; No control of status epilepticus with first line drugs such as diazepam, Phenytoin and Phenobarbital. exclusion criteria: all children with acute or chronic liver disease ; all children with metabolic disease ; seizure in children with trauma ; all children with coagulation disfunction
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Status epilepticus treatment. Timepoint: before prevention and 24 hours after prevention. Method of measurement: questionarie. | — |
Secondary
| Measure | Time frame |
|---|---|
| Complications of treatment. Timepoint: during first 72 hours of prevention. Method of measurement: questionarie. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMotahareh Kheradmand
Mazandaran Univercity of Medical sciences and Health ervices
Outcome results
None listed