Atrial fibrillation. Atrial fibrillation and flutter
Conditions
Interventions
Intervention 1: for internention:
Intravenous Amiodarone 150 mg over 10 minutes followed by a 50 mg per hour slow infusion for 3 hours then 25 mg per hour for 8 hours. Intervention 2: For control:
Di
Treatment - Drugs
for internention:
Intravenous Amiodarone 150 mg over 10 minutes followed by a 50 mg per hour slow infusion for 3 hours then 25 mg per hour for 8 hours.
For control:
Digoxin is given in an initial slow intravenous dose of 0.5 mg then if needed 0.25 mg in hours 2 and 4 of intervention.
Sponsors
Shahid Beheshti University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: All patients with over 110 beats per minute Atrial Fibrillation who are referred to emergency room Exclusion criteria: patients with unstable vital signs who are needed electrical cardioversion; or due to underline diseases such as sepsis, anemia, bleeding, hypovolemia who are needed treatment under 18 or over 80 years; who haven't congestive heart failure; who have received antiarrhythmic agents last 12 hours; who couldn't monitoring 12 hours during the study who are not willing to participate in this study; presence of hepatic or renal dysfunction; atrial fibrillation diagnosis isn't definite in ECG;
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Heart rate. Timepoint: Before the intervention,and during 12 hours of the intervention and one week after intervention. Method of measurement: Heart rate based on ECG and cardiac monitoring. | — |
Secondary
| Measure | Time frame |
|---|---|
| Time to response. Timepoint: During 12 hours of intervention. Method of measurement: Heart rate based on ECG and cardiac monitoring.;Decrease in blood pressure more than 20 mmHg. Timepoint: During 12 hours of intervention. Method of measurement: Standard sphygmomanometer 2 times with 2 persons.;Decrease in heart rate less than 60 beats per minute. Timepoint: Every 1 hour during 12 hours of intervention. Method of measurement: Heart rate based on ECG and cardiac monitoring.;Occurrence of other arrhythmias. Timepoint: During 12 hours of intervention. Method of measurement: Based on ECG and cardiac monitoring. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr Majid Shojaee
Shahid Beheshti Medical University
Outcome results
None listed