Diabetes mellitus. Non-insulin dependent diabetes mellitus
Conditions
Interventions
Intervention 1: glutamine ( 3 times a day for 6 weeks). Intervention 2: cellulose (3 times a day for 6 weeks).
Treatment - Drugs
glutamine ( 3 times a day for 6 weeks)
cellulose (3 times a day for 6 weeks)
Sponsors
Endocrinology & Metabolism Research Institute, Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
30 Years to 65 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: Patient diagnosed with type 2 diabetes based on ADA definition or who only take oral antidiabetic drug Exclusion criteria: history of drug dependence; body mass index (BMI) =35 kg/m2; history of cancer; treatment with anti-inflammatory; corticosteroid; hormonal or antibiotic agents; a restrictive diet or weight change = 5 kg during the 3months prior to study; systolic blood pressure >160 mmHg and/or diastolic blood pressure > 90 mmHg; fatty liver disease; liver or kidney disease; autoimmune disease; pregnancy and lactation; any change in treatment with oral hypoglycemic; anti hypertensive and antilipid agents during the study; use of weight loss medications; HbA1C >8
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fast blood sugar. Timepoint: Before and 6 weekes after the intervention. Method of measurement: mg/ dl / enzymatic.;GLP-1 ( Glucagon- like peptide-1). Timepoint: Before and 6 weekes after the intervention. Method of measurement: pmol/ l / ELISA.;Serum insulin. Timepoint: Before and 6 weekes after the intervention. Method of measurement: pmol/ l / IRMA method.;Serum c peptide. Timepoint: Before and 6 weekes after the intervention. Method of measurement: mg/ l.;Hs- CRP. Timepoint: Before and 6 weekes after the intervention. Method of measurement: ELSA.;Resting energy expenditure. Timepoint: Before and 6 weekes after the intervention. Method of measurement: indirect calorimetry. | — |
Secondary
| Measure | Time frame |
|---|---|
| Srum glutamine. Timepoint: Before and 6 weekes after the intervention. Method of measurement: spectrophotometric.;Blood pressure. Timepoint: Before and 6 weekes after the intervention. Method of measurement: blood pressure,sphygmomanometer.;Total cholestrol. Timepoint: Before and 6 weekes after the intervention. Method of measurement: mg/ dl.;HDL-C. Timepoint: Before and 6 weekes after the intervention. Method of measurement: mg/ dl.;LDL-C. Timepoint: Before and 6 weekes after the intervention. Method of measurement: mg/dl.;Hb A1C. Timepoint: Before and 6 weekes after the intervention. Method of measurement: fast HbA1c serum level,Chromatography.;Serum creatinine. Timepoint: Before and 6 weekes after the intervention. Method of measurement: mg/dl.;Body composition. Timepoint: Before and 6 weekes after the intervention. Method of measurement: Tanita body composition analyzer.;Triglyceride. Timepoint: Before and 6 weekes after the intervention. Method of measurement: mg/dl. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAsieh Mansour
Endocrinology & Metabolism Research Institute Tehran University of Medical Sciences
Outcome results
None listed