Investigating and comparing the therapeutic outcomes of two regimens of cholestin therapy through a bronchoscope versus standard treatment in patients with lung infection

Investigating and comparing the therapeutic outcomes of two treatment regimens of cholestin instillation (through the bronchoscope) versus standard treatment in patients with ventilator-associated pneumonia (VAP) with resistant gram-negative bacilli.

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20120527009886N3

Enrollment

Registered

2023-04-11

Start date

2023-04-18

Completion date

Unknown

Last updated

2023-05-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ventilator Associated Pneumonia. Ventilator associated pneumonia

Interventions

Intervention 1: Intervention group: Instillation Bronchoscopy. Intervention 2: Control group: Clostin nebulizer.

Eligibility

Sex/Gender

All

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: Patients with ventilator-associated pneumonia Age between 18 and 75 years Patients who developed pulmonary infection with gram-negative bacilli resistant to several antibiotic drugs after 48 hours of intubation.

Exclusion criteria

Exclusion criteria: Age older than 75 or younger than 18 years Patients with adult respiratory distress syndrome (ARDS) according to the Berlin criteria P/F ratio less than 100 Septic shock requires a dose of norepinephrine with a dose greater than 0.25 Mcg/KG/MIN Patients with infection with other microorganisms

Design outcomes

Primary

Measure	Time frame
Mortality rate. Timepoint: After the start of treatment until the discharge or death of the patient. Method of measurement: Questionnaire.	—

Secondary

Measure	Time frame
The number of days hospitalized in the intensive care unit. Timepoint: After initiation of treatment until discharge or death from the intensive care unit. Method of measurement: Questionnaire.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMostafa Mohammadi

Tehran University of Medical Sciences

mohammady_mm@tums.ac.ir0098.21.61190

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026