Colon cancer. Malignant neoplasm of colon
Conditions
Interventions
Intervention 1: Control group: They will receives a placebo (oral pill) the night before the operation and a placebo (normal saline solution) after induction of anesthesia. Intervention 2: Interventio
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Candidates for elective colorectal cancer surgery Patient age between 18 and 70 years Patient consent to participate in the plan Non-participation of the patient in another drug clinical trial
Exclusion criteria
Exclusion criteria: Emergency surgeries Non-consent Multiple trauma cases Age more than 70 years Candidate patients for multiple surgeries (or second or third surgery cases) Chronic renal failure patients (or single kidney patients or patients with GFR less than 20% of normal) Patients with a history of ascites or liver cirrhosis Patients with a history of anaphylactic reactions to melatonin, ketamine, or propofol Patients with heart failure (cardiac ejection fraction less than 25%) Patients with ischemic heart disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative delirium. Timepoint: 12 and 24 hours after surgery. Method of measurement: Confusion Assessment Method-Intensive Care Unit. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMostafa Mohammadi
Tehran University of Medical Sciences
Outcome results
None listed