Level of consciousness and cognitive function in patients with trauma.
Conditions
Interventions
Intervention 1: Intervention group: Patients aged 18 to 65 years with severe brain trauma will receive twice daily Amantadine 100 mg once a day, and this dose will continue for 11 days. At week 3, the
Sponsors
Tabriz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1- Patients aged 18 to 65 years 2. Those who have not had a known disease prior to head injury. 3. The supervisor will provide his written consent on his behalf
Exclusion criteria
Exclusion criteria: 1-People with severe cardiovascular disease or congestive heart failure, myocardial infarction, persistent spinal cord injury, cancer, or any other severe disease that affects the evaluation of treatment. 2-People with chronic steroid therapy 3-Individuals received any other drug within 30 days of injury. 4-Significant TBI, brain tumor, cerebrovascular event, or other persistent brain illusions
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mini-mental Status Test (MMSE) scoring for patients with severe acute trauma. Timepoint: During surgery and duration of hospitalization after surgery. Method of measurement: Check out the Mini-mental Status Test (MMSE) table.;Disability Rating Scale (DRS) scoring for patients with severe acute traumatic brain injury. Timepoint: During surgery and duration of hospitalization after surgery. Method of measurement: Disability Rating Scale (DRS) Score.;Glasgow Outcome Scale Scoring (GOS) for patients with severe acute traumatic brain injury. Timepoint: During surgery and duration of hospitalization after surgery. Method of measurement: Check Glasgow Outcome Scale Table (GOS). | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMoslem Shakeri
Tabriz University of Medical Sciences
Outcome results
None listed