STEMI. ST elevation (STEMI) myocardial infarction of unspecified site
Conditions
Interventions
Intervention 1: Intervention group: Patients under PCI who receive trans sodium crocetinate"""(TSC) at a dose of 0.5 mg / kg body weight by injection within 2 minutes, 5 minutes before PCI, in additio
Sponsors
Mashhad University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 76 Years
Inclusion criteria
Inclusion criteria: Patients should be between 18 and 76 years old Patients with myocardial infarction with an ascending ST segment Meet the entry requirements under the AHA2019 guideline Candidates for PPCI Zero TIMI score at admission
Exclusion criteria
Exclusion criteria: Be pregnant or breastfeeding History of allergy to formulations used in the study.• The patient enters another similar plan and receives other drugs that affect treatment response in the past month The person has cardiogenic shock and is forced to use pressure therapy The patient has IABP History of acute myocardial infarction GFR less than 60 ml / min• Patients with cardiac arrest Patient with VF Patient with hepatic impairment AST / ALT> 5ULN Patient with a history of chronic inflammatory disease Patient with LMCA involvement Patient with a history of myocardial infarction or ACS within 4 hours before the current episode
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Quantitative amounts of Troponin I Tn I enzyme and drawing the shape of the Tn I time concentration curve. Timepoint: At zero time, 6, 12 and 24 hours after PPCI. Method of measurement: High-Sensitivity Troponin Test-Laboratory. | — |
Secondary
| Measure | Time frame |
|---|---|
| Evaluation of the patient's electrocardiogram and recording of ventricular and supraventricular arrhythmias, number of PVCs, PR / QT / QRS intervals, and evaluation of the cumulative amount of ST segment (STR Percentage). Timepoint: Daily until discharge. Method of measurement: Through ECG examination.;Ejection fraction and evaluation of systolic and diastolic status of all 4 chambers of the heart and LV ENLARGMENT. Timepoint: Daily until discharge. Method of measurement: Echocardiography.;Evaluation of biochemical parameters INR, BUN, Scr Na, K, Ca, Mg, ALT, AST. Timepoint: Daily until discharge. Method of measurement: Laboratory.;Evaluation of the balance between oxidants - antioxidants. Timepoint: Two samples at time zero and patient discharge time. Method of measurement: Laboratory. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAmir Hooshang Mohammadpour
Mashhad University of Medical Sciences
Outcome results
None listed