Evaluation of the effect of crocin on prevention of atrial fibrillation after heart surgery

Evaluation of the effect of crocin on prevention of atrial fibrillation after coronary artery bypass grafting (CABG) or valve replacement: a triple-blind, randomized, placebo-controlled trial

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20120520009801N4

Enrollment

Registered

2020-12-15

Start date

2020-11-21

Completion date

Unknown

Last updated

2021-01-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Atrial fibrillation after heart surgery. Paroxysmal atrial fibrillation

Interventions

Intervention 1: Intervention group: It includes patients who receive 15 mg crocin tablets made by Sami Saz under the brand name Krocina twice a day for three days before to three days after surgery. T

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: Candidates for heart surgery including CABG or valve replacement 70 yr > age > 18 yr Taking ACEIs/ARBs, beta-blockers, statins and aspirin for CABG patients

Exclusion criteria

Exclusion criteria: Have pacemaker Renal failure (45 = GFR) Hepatic failure (hepatic enzymes > 3 times of upper normal limit ) Sensitivity to crocin or saffron History of taking anti-inflammatory or anti-oxidant drugs via two weeks before surgery Thyroid dysfunction Have AF rhythm History of heart surgery Pregnancy and lactation

Design outcomes

Primary

Measure	Time frame
The incidence of atrial fibrillation. Timepoint: Through 72 hrs after heart surgery. Method of measurement: Holter monitoring.	—

Secondary

Measure	Time frame
Hs-CRP blood concentration. Timepoint: Before surgery and 3 days after surgery. Method of measurement: Laboratory.;Oxidative stress. Timepoint: Before surgery and 3 days after surgery. Method of measurement: Laboratory - malondialdehyde assay.;The incidence of ventricular and supra-ventricular arrhythmias. Timepoint: Through 72 hrs after heart surgery. Method of measurement: Holter monitoring.;Lenght of hospital stay. Timepoint: From heart surgery to discharge. Method of measurement: Counting of hospitalizations days.	—

Measure

Time frame

Hs-CRP blood concentration. Timepoint: Before surgery and 3 days after surgery. Method of measurement: Laboratory.;Oxidative stress. Timepoint: Before surgery and 3 days after surgery. Method of measurement: Laboratory - malondialdehyde assay.;The incidence of ventricular and supra-ventricular arrhythmias. Timepoint: Through 72 hrs after heart surgery. Method of measurement: Holter monitoring.;Lenght of hospital stay. Timepoint: From heart surgery to discharge. Method of measurement: Counting of hospitalizations days.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactAmir Hooshang Mohammadpour

Mashhad University of Medical Sciences

mohamadpoorah@mums.ac.ir+98 51 1882 3255

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026