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Resveratrol effect on atrial fibrillation

Evaluation of the Effect of Oral Resveratrol on Prevention of Atrial Fibrillation After Coronary Artery Bypass Grafting (CABG): a Double-blind, Randomized, Placebo-controlled Trial (phase 3 clinical trial)

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20120520009801N16
Enrollment
132
Registered
2025-07-05
Start date
2025-07-06
Completion date
Unknown
Last updated
2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Atrial fibrillation after heart surgery. Paroxysmal atrial fibrillation

Interventions

Intervention 1: Intervention group: It includes patients who receive 4 capsules of 250 mg of resveratrol made by Raha pharmaceutical company once daily for three days before to three days after surger

Sponsors

Mashhad University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 70 Years

Inclusion criteria

Inclusion criteria: Candidates for heart surgery CABG 70 yr > age > 18 yr Taking ACEIs/ARBs, beta-blockers, statins and aspirin for CABG patients

Exclusion criteria

Exclusion criteria: Severe heart failure (NYHA Class IV) Renal failure (20 = GFR) Hepatic failure (hepatic enzymes > 3 times of upper normal limit ) pregnancy Have pacemaker Have AF rhythm History of heart surgery Very thin people (BMI = 18.5 kg/m2)

Design outcomes

Primary

MeasureTime frame
The incidence of atrial fibrillation. Timepoint: Through 72 hrs after heart surgery. Method of measurement: Holter monitoring.

Secondary

MeasureTime frame
C-Reactive Protein (CRP) blood concentration. Timepoint: Before surgery and 3 days after surgery. Method of measurement: Laboratory.;The incidence of ventricular and supra-ventricular arrhythmias. Timepoint: Through 72 hrs after heart surgery. Method of measurement: Holter monitoring.;Lenght of hospital stay. Timepoint: From heart surgery to discharge. Method of measurement: Counting of hospitalizations days.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactZahra Jahani

Mashhad University of Medical Sciences

Jahaniz4012@mums.ac.ir+98 51 3522 3258

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026