Difference between Amiodarone and Lidocaine in the incidence of arrhythmia after cardiac surgery

Comparing the efficacy of Amiodarone and Lidocaine in the incidence of cardiac arrhythmia after coronary artery bypass graft surgery

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT201205198860N2

Enrollment

150

Registered

2012-05-31

Start date

2012-06-21

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ischemic Heart Disease. Ischemic Heart Disease

Interventions

Intervention 1: Treatment (A): Lidocaine (4 mg/kg) will be added to the prime before removal of aortic cross clamp. Intervention 2: Treatment (B): Amiodarone (150 mg) will be added to the prime before

Prevention

Placebo

Treatment (A): Lidocaine (4 mg/kg) will be added to the prime before removal of aortic cross clamp

Treatment (B): Amiodarone (150 mg) will be added to the prime before removal of aortic cross clamp.

Control (C): Normal saline (5 cc) will be added to the pomp solution before removal of aortic cross clamp.

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Inclusion criteria: 1. Age > 18; 2. patients with coronary artery disease who need CABG surgery; 3. On-pump surgery; 4. In Dr.Ghavidel and Dr.Khamooshi's service; 5. negative history of ventricular arrhythmia before surgery. Exclusion criteria: 1. Requiring concomitant surgery; 2. Reject to enter to this study; 3. Any known history of sensitivity to Lidocaine or Amiodarone.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Incidence of cardiac arrhythmia after cardiac surgery. Timepoint: After removal of aortic cross clamp, during ICU stay, during ward stay. Method of measurement: Holter monitoring.	—

Secondary

Measure	Time frame
Mortality rate. Timepoint: 30 days after operation. Method of measurement: Interview, phone call.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Alireza Alizadeh Ghavidel

Rajaei Heart Center

aaghavidel@gmail.com, aghavidel@rhc.ac.ir+98 21 2392 2147

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026