Major Depressive episode. Depressive episode
Conditions
Interventions
Intervention 1: Capsule Fluoxetine 40 mg/day plus Capsule simvastatin 20 mg/day as intervention group for 6 weeks. Intervention 2: Cap fluoxetine 40 mg/day plus Cap. placebo as control group for 6 wee
Treatment - Drugs
Placebo
Capsule Fluoxetine 40 mg/day plus Capsule simvastatin 20 mg/day as intervention group for 6 weeks
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Inclusion criteria: Presence of Major Depressive Disorder based on DSM-IV criteria, Baseline Hamilton Depression Rating Scale (HAM-D) (17-item) score of at least 22. Exclusion criteria: Presence of Psychosis, any diagnosis in Axis I and II, Receiving psychotropic medications, receiving any antidepressants during past one month or ECT during past two months, Presence of hypothyroidism or cardiovascular problems, hepatic disease, muscular disease, receiving other drugs affecting lipids, hypersensitivity to statins, LDL<80, high levels of liver enzymes at the beginning of the study, any life threatening condition, neurological disease, nursing and pregnant women
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Severity ofdepression. Timepoint: Baseline and weeks 2-4-6 after beginig of treatment. Method of measurement: by Hamiltion Depression Rating Scale 17-Item. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactProf. Shahin Akhondzadeh
Tehran University of Medical Sciences
Outcome results
None listed