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The effect of low dose Aspirin in increasing the chance of pregnancy

To evaluate the effect of low dose Aspirin in increasing the chance of pregnancy in frozen embryo transfer cycles

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT201205131141N12
Enrollment
60
Registered
2012-07-13
Start date
2012-05-01
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infertility. Female infertility

Interventions

Intervention 1: With the onset of endometrial preparation and estrogen treatment, the study group will receive 100 mg of oral aspirin. Intervention 2: With the onset of endometrial preparation and est
Treatment - Drugs
Placebo
With the onset of endometrial preparation and estrogen treatment, the study group will receive 100 mg of oral aspirin.
With the onset of endometrial preparation and estrogen treatment, the control group will receive placebo.

Sponsors

Royan Institute
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 40 Years

Inclusion criteria

Inclusion criteria: Patients with "long or antagonist" protocol; Women who did not achieve a pregnancy following a fresh embryo transfer or women whom their embryos had not been transferred due to OHSS; The women who had frozen embryos available for another transfer. Exclusion Criteria: The patients with history of recurrent abortion, contraindications for aspirin.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Clinical pregnancy. Timepoint: 4-6 weeks after embryo transfer. Method of measurement: Ultrasound visualization of a gestational sac.

Secondary

MeasureTime frame
Implantation rate. Timepoint: 4-6 weeks after embryo transfer. Method of measurement: Number of sacs by Sonography.;Early abortion. Timepoint: Week 12. Method of measurement: Sonography.;Biochemical pregnancy. Timepoint: 2 weeks after embryo transfer. Method of measurement: BhCG test.;Endometrial thickness. Timepoint: Third day & Embryo transfer day. Method of measurement: Sonography.;Late abortion. Timepoint: Week 20. Method of measurement: Sonography.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr.Tahereh Madani

Roan Institute

tmadani@royaninstitute.org+98 21 2235 2008

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026