Assessment of the effects of diclofenac suppository and intravenous acetaminophen, and the combination of them, on postoperative pain in patients undergoing spinal anesthesia for cesarean section

The effects of diclofenac suppository and intravenous acetaminophen, and the combination of them, on postoperative pain in patients undergoing spinal anesthesia for cesarean section

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT201205099697N1

Enrollment

Registered

2015-01-27

Start date

2014-04-03

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

?Acute Pain. ?Acute Pain

Interventions

Intervention 1: Diclofenac suppositories 100 mg, based on average pain severity of patients evaluated at Hour 0, 2, 4, 6, 12, 24 after local anesthetic in the recovery unit, will be prescribed. Aboure

Treatment - Drugs

Diclofenac suppositories 100 mg, based on average pain severity of patients evaluated at Hour 0, 2, 4, 6, 12, 24 after local anesthetic in the recovery unit, will be prescribed. Aboureihan Pharmaceuti

intravenous acetaminophen 1000mg? based on average pain severity of patients evaluated at Hour 0, 2, 4, 6, 12, 24 after local anesthetic in the recovery unit, will be prescribed. Daroupakhsh Pharmaceu

Combination of diclofenac suppository 100 mg and 500 mg intravenous acetaminophen, based on average pain severity of patients at hour 0, 2, 4, 6, 12, 24 post-local anesthetic in recovery unit, will be

Eligibility

Sex/Gender

Female

Age

17 Years to 40 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Patients with 1 and 2 ASA class of Anesthesia; Term gestational age; absence of chronic diseases such as cardiovascular; hepatic and renal disease. exclusion criteria: hypersensitivity to any drug such as acetaminophen; local anesthetics, having liver or renal disease; diabetes, and patients who used analgesic drugs (opioids, NSAID and corticosteroid)within 8 to 12 hours before the intervention

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Determination of pain severity before intervention in patients undergoing spinal anesthesia for cesarean section in diclofenac suppository group in Sayyad Shirazi Hospital of Gorgan. Timepoint: before intervention. Method of measurement: Visual Analogue Scale (VAS).;Determination of pain severity before intervention in patients undergoing spinal anesthesia for cesarean section in intravenous acetaminophen group in Sayyad Shirazi Hospital of Gorgan. Timepoint: before intervention. Method of measurement: Visual Analougue Scale(VAS).;Determination of pain severity before intervention in patients undergoing spinal anesthesia for cesarean section in combination of the intravenous acetaminophen and diclofenac suppository group in Sayyad Shirazi Hospital of Gorgan. Timepoint: before intervention. Method of measurement: Visual Analougue Scale (VAS).;Determination of pain severity after intervention in patients undergoing spinal anesthesia for cesarean section in group of diclofenac suppository in Sayyad Shirazi Hospital of Gorgan. Timepoint: in hour 0, 2, 4, 6, 12, 24. Method of measurement: Visual Analougue Scale.;Determination of pain severity after intervention in patients undergoing spinal anesthesia for cesarean section in group of intravenous acetaminophen in Sayyad Shirazi Hospital of Gorgan. Timepoint: in hour 0, 2, 4, 6, 12,24. Method of measurement: Visual Analougue Scale (VAS).;Determination of pain severity after intervention in patients undergoing spinal anesthesia for cesarean section in combination of the intravenous acetaminophen and diclofenac suppository group in Sayyad Shirazi Hospital of Gorgan. Timepoint: in hour 0? 2 ?4 ?6 ?12? 24. Method of measurement: Visual Analougue Scale (VAS).;Comparison of pain severity after the intervention in patients undergoing spinal anesthesia for cesarean section groups of acetaminophen, diclofenac, and the combined intravenous acetaminophen and diclofenac suppository in Sayyad Shirazi Hospital of Gorgan. Timepoint: in	—

Measure

Time frame

Determination of pain severity before intervention in patients undergoing spinal anesthesia for cesarean section in diclofenac suppository group in Sayyad Shirazi Hospital of Gorgan. Timepoint: before intervention. Method of measurement: Visual Analogue Scale (VAS).;Determination of pain severity before intervention in patients undergoing spinal anesthesia for cesarean section in intravenous acetaminophen group in Sayyad Shirazi Hospital of Gorgan. Timepoint: before intervention. Method of measurement: Visual Analougue Scale(VAS).;Determination of pain severity before intervention in patients undergoing spinal anesthesia for cesarean section in combination of the intravenous acetaminophen and diclofenac suppository group in Sayyad Shirazi Hospital of Gorgan. Timepoint: before intervention. Method of measurement: Visual Analougue Scale (VAS).;Determination of pain severity after intervention in patients undergoing spinal anesthesia for cesarean section in group of diclofenac suppository in Sayyad Shirazi Hospital of Gorgan. Timepoint: in hour 0, 2, 4, 6, 12, 24. Method of measurement: Visual Analougue Scale.;Determination of pain severity after intervention in patients undergoing spinal anesthesia for cesarean section in group of intravenous acetaminophen in Sayyad Shirazi Hospital of Gorgan. Timepoint: in hour 0, 2, 4, 6, 12,24. Method of measurement: Visual Analougue Scale (VAS).;Determination of pain severity after intervention in patients undergoing spinal anesthesia for cesarean section in combination of the intravenous acetaminophen and diclofenac suppository group in Sayyad Shirazi Hospital of Gorgan. Timepoint: in hour 0? 2 ?4 ?6 ?12? 24. Method of measurement: Visual Analougue Scale (VAS).;Comparison of pain severity after the intervention in patients undergoing spinal anesthesia for cesarean section groups of acetaminophen, diclofenac, and the combined intravenous acetaminophen and diclofenac suppository in Sayyad Shirazi Hospital of Gorgan. Timepoint: in

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactFozieh Bakhsha

Golestan University of Medical Sciences

Bakhsha2goums.ac.ir? Bakhsha_fo@yahoo.com? Bakhshafo@gmail .com+98 17 3253 8011

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026