Clinical effects of subantimicrobial dose doxycycline

Evaluation of the effect of doxycycline 20 mg as an adjunct to scaling and root planing in mild periodontitis patients

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT201205058205N2

Enrollment

Registered

2012-05-21

Start date

2011-07-08

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Clinical effects of subantimicrobial dose doxycycline. Other specified disorders of teeth and supporting structures

Interventions

Intervention 1: Internention 2: control group: after scaling and root planing, patients used the placebo (containig starch) twice daily and for 3 months, orally. Intervention 2: Intervention 1: case g

Treatment - Drugs

Internention 2: control group: after scaling and root planing, patients used the placebo (containig starch) twice daily and for 3 months, orally.

Intervention 1: case group: After scaling and root planing, patients received capsules containing subantimicrobial dose doxycyline (2o mg) twice daily and for 3 months, orally.

Eligibility

Sex/Gender

All

Age

25 Years to 54 Years

Inclusion criteria

Inclusion criteria: Inclusion criterion: having at leat 14 untreated teeth with mild periodontitis in two quadrantsthat need comprehensive treatment. Exclusion criteria were: pregnant women; patients with a history of tetracycline sensitivity; any sytemic infection requiring antibiotic prophylaxy for dental procedures; history of intake of tetracycline during the 3 last months; history of periodontal therapy (scaling and root planing or periodontal surgery) during the last 3 months.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
PPD: The distance between the gingival margin and depth of sulcus. Timepoint: Before treatment, 3 months after treatment. Method of measurement: Periodontal probe, mm.	—

Secondary

Measure	Time frame
BOP: bleeding on probing. Timepoint: Before treatment, 3 months after treatment. Method of measurement: Periodontal probe,mm.;CAL: The distance between cementoenamel junction (CEJ) and the bottom of pocket. Timepoint: Before treatment, 3 months after treatment. Method of measurement: Periodontal probe,mm.;MGI: a gingival index for evaluation of gingival health. Timepoint: Before treatment, 3 months after treatment. Method of measurement: Periodontal probe,mm.	—

Measure

Time frame

BOP: bleeding on probing. Timepoint: Before treatment, 3 months after treatment. Method of measurement: Periodontal probe,mm.;CAL: The distance between cementoenamel junction (CEJ) and the bottom of pocket. Timepoint: Before treatment, 3 months after treatment. Method of measurement: Periodontal probe,mm.;MGI: a gingival index for evaluation of gingival health. Timepoint: Before treatment, 3 months after treatment. Method of measurement: Periodontal probe,mm.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Mohammad Reza Amjadi

Isfahan University of Medical Sciences, Faculty of dentistry

amjadi@dnt.mui.ac.ir+98 31 1792 2842

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026