Diabetes mellitus. Non-insulin-dependent diabetes mellitus
Conditions
Interventions
Intervention 1: Intervention:Patients randomized to double-blind treatment will be with cabergoline 5 / 0 mg once a week for three months. Intervention 2: Contro:Patients randomized to double-blind tr
Treatment - Drugs
Intervention:Patients randomized to double-blind treatment will be with cabergoline 5 / 0 mg once a week for three months
Contro:Patients randomized to double-blind treatment will be with Placebo 5 / 0 mg once a week for three months
Sponsors
Mazandaran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
20 Years to 80 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria :Type 2 diabetes diagnosed at least three months prior to study entry? greater than or equal treatment 2 Oral medication to control blood sugar With at least 50% of recommended dose? Age between 20 to 80 years; A1C hemoglobin more than %7.5 at the time of study entry? Reliable method of contraception in women of reproductive age entered the study. Exclusion criteria: Unwillingness of the patient? known immunodeficiency? pregnancy and lactation, cardiovascular disease? taking drugs that have effects on blood sugar levels include: corticosteroids and thiazide?Uncontrolled thyroid disease?History of diabetic ketoacidosis-Creatinine above 2-Liver and kidney disease? known allergy to cabergoline?proliferative retinopathy; HA1C >10% and severe weight loss
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cabergoline effects on glycemic control. Timepoint: After the first and second trimester of intervention. Method of measurement: Blood tests. | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum Insulin. Timepoint: Before Intervention and the end of each three Months afterIntervention. Method of measurement: Blood test.;Prolactin. Timepoint: Before Intervention and the end of each three Months after Intervention. Method of measurement: Blood test.;Hypertension. Timepoint: Before Intervention and the end of each three Months after Intervention. Method of measurement: Barometer.;Weight. Timepoint: Before Intervention and the end of each three Months after Intervention. Method of measurement: Balance.;Waist size. Timepoint: Before Intervention and the end of each three Months after Intervention. Method of measurement: Meter.;Blood Urea Nitrogen. Timepoint: Before Intervention and the end of each three Months after Intervention. Method of measurement: Blood test.;Creatinine. Timepoint: Before Intervention and the end of each three Months after Intervention. Method of measurement: Blood test.;Aspartate Aminotransferase. Timepoint: Before Intervention and the end of each three Months after Intervention. Method of measurement: Blood test.;Alanine Aminotransferase. Timepoint: Before Intervention and the end of each three Months after Intervention. Method of measurement: Blood test. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr Adeleh Bahar
Mazandaran University of Medical Sciences
Outcome results
None listed