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Effect of two traditional formulations from Syrian Rue and Zaatar for osteoarthritis

Formulation and clinical trial of two traditional formulations from Peganum harmala and Zataria multiflora for knee osteoarthritis

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT201205029622N1
Enrollment
81
Registered
2012-08-30
Start date
2012-01-16
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ostearthritis. Primary arthrosis NOS

Interventions

Intervention 1: Group A: Zaatar oil, 3 times per day, 4 drops each time on knee. Intervention 2: Group B: Syrian Rue oil,3 times per day, 4 drops each time on knee for 4 weeks. Intervention 3: Group C
Treatment - Drugs
Placebo
Group A: Zaatar oil, 3 times per day, 4 drops each time on knee.
Group B: Syrian Rue oil,3 times per day, 4 drops each time on knee for 4 weeks.
Group C:Placebo, 3 times per day, 4 drops each time on knee for 4 weeks.

Sponsors

Department of Traditional Pharmacy, School of Pharmacy,Shiraz University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
40 Years to 75 Years

Inclusion criteria

Inclusion criteria: Inclusion: Diagnosis of knee OA based on ACR criteria; Complained of knee pain with intensity of at least 30 according to the VAS scale of 0-100; Not using steroidal, non steroidal and opioid analgesics since entering the study; Not using noninflammatory and immunosuppressive medications; Disease severity Mild to moderate. Exclusion: Severe reduction of joint space in radiographic findings; Pregnancy; Simultaneous joint diseases including rheumatoid arthritis; Chronic inflammatory diseases; Osteoporosis and osteopenia.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Knee pain from osteoarthritis. Timepoint: before study, 4 weeks after. Method of measurement: Womac questionary and VAS.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactZohreh Abolhassanzadeh

Department of Traditional Pharmacy, School of Pharmacy, Shiraz Univercity of Medical Sciences

abolhasanz@sums.ac.ir+98 71 1242 4255

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026