?Evalaution of anti-tumoral effects of sera isolated from lidocaine and fentanyl infusion in the patients with breast cancer

The effects of lidocaine infusion versus fentanyl on breast cancer cells apoptosis in patient under breast cancer surgery

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20120430009593N14

Enrollment

Registered

2021-01-19

Start date

2021-01-20

Completion date

Unknown

Last updated

2021-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Breast cancer. Malignant neoplasm of breast of unspecified site

Interventions

Intervention 1: Control group: Fentanyl infusion during anesthesia at a dose of 2 microg /kg until the end of surgery. Caspian Tamin Pharmaceutical Company. Intervention 2: Intervention group: Infusio

Eligibility

Sex/Gender

Female

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: female 18 to 75 years old candiadate for mastectomy due to breast cancer ASA I,II

Exclusion criteria

Exclusion criteria: History of cardiac arrhythmias ASA IV Inflammation and infection at the surgical site History of seizures History of liver disease History of previous breast surgery except than breast biopsy Kidney failure Addiction History of mental illness

Design outcomes

Primary

Measure	Time frame
Cancer Cell Apoptosis Index. Timepoint: Evaluation of apoptosis index in breast cancer cells after 12, 24 and 48 hours of serum exposure. Method of measurement: Measurement of Caspase 3, Caspase 8 and Caspase 9 factors based on immunocytochemical techniques.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactElham Memary

Shahid Beheshti University of Medical Sciences

drmemary@gmail.com+98 21 7756 7840

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026