Knee Osteoarthritis. Gonarthrosis [arthrosis of knee]
Conditions
Interventions
Intervention 1: Drug (Garlic tablet 500 Mg, Twice a day for 3 month). Intervention 2: Placebo twice a day for 3 month.
Treatment - Drugs
Placebo
Drug (Garlic tablet 500 Mg, Twice a day for 3 month)
Placebo twice a day for 3 month
Sponsors
Tehran University Of Medical Sciences
Eligibility
Sex/Gender
Female
Age
50 Years to 75 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: women; 50-75 years old; postmenopausal; obese body mass index between 25 - 35 with moderate and severe knee osteoarthritis Diagnosis by rheumatologist. Exclusion criteria:severe pain or hip involvement; candidate for surgery; had a knee sergery; sensitivity of garlic; smoking; history of cardiovascular disease; type 1 diabetes; liver disease; hypo or hyper thyroid; kidney disease; arthritis; gout; cancer; any injection in knee in 3 month before intervention; intake of NSAIDs; HRT; astatine; warfarin and supplement like omega 3 or 6 and condroitin sulphate; being in a diet or weight loss about 5% during 3 month in this study.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Resistin. Timepoint: Week 12. Method of measurement: Lab kit.;Tumor Necrosis Factor-Alpha. Timepoint: Week 12. Method of measurement: kit. | — |
Secondary
| Measure | Time frame |
|---|---|
| Body Composition (Fat mass, Fat Free Mass). Timepoint: Week 12. Method of measurement: Bio Electrical Impedance.;Fasting Blood Sugar. Timepoint: Week 12. Method of measurement: ELISA kit.;Weigth. Timepoint: Week 12. Method of measurement: Balance. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSahar Dehghani
Tehran University Of Medical Sciences
Outcome results
None listed