Evaluation of the effect of injection of bupivacaine by patient into the tooth socket on pain management after surgical extraction of impacted lower third molar

Clinical trial to comparison of bupivacaine(local) and mefnamic acid on mean pain score reported during the first 24 hours after surgical extraction of third molar, in patients with similar bilateral impacted lower third molar.

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT201204199515N1

Enrollment

Registered

2013-01-15

Start date

2012-04-19

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

impacted teeth. An impacted tooth is a tooth that has failed to erupt because of obstruction by another tooth

Interventions

Intervention 1: Intervention group: Placebo of mefnamic acid 250 mg, every 8 hours during 24 hours following surgery. Intervention 2: Intervention group: Injection of 0.3 cc bupivacaine 0.5% in to th

Placebo

Treatment - Drugs

Intervention group: Placebo of mefnamic acid 250 mg, every 8 hours during 24 hours following surgery.

Intervention group: Injection of 0.3 cc bupivacaine 0.5% in to the tooth socket, every 2 hours during 12 hours following surgery.

Control group: Injection of 0.3cc normal saline in to the tooth socket, every 2 hours during 12 hours following surgery.

Control group: Mefnamic acid 250 mg, every 8 hours during 24 hours following surgery.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Major inclusion criteria: The patients with similar bilateral impacted lower third molar; Patients that have no contraindications for oral surgery; Patients that are able to understand the method of our study. Major exclusion criteria: The length of two surgery of one patient have more than 10 min difference; Not using of drug according to the method that is trained.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Post surgical pain. Timepoint: 24 hours following surgery. Method of measurement: Visual Analogue Scale.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactIdeh Talimkhani

Hamadan faculty of dentistry

ideatalimkhani@yahoo.com, i.talimkhani@umsha.ac.ir+98 81 1824 2144

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026