Condition 1: wheat allergy. Condition 2: Desensitization. Adverse effects, not elsewhere classified Desensitization to allergens
Conditions
Interventions
The anaphylactic patients take Loratadine and Montelukast, three days prior to admission to prevent the severe adverse reaction. On the first day of admission
we perform OFC again with premedication, so we determine the initial dose of rush OIT. In rush phase, patients take bread two time a day, and if they can take them without severe reactions, they are
Treatment - Other
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
5 Years to 60 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: patients above 5 years with IgE mediated wheat allergy (positive skin prick test response to wheat flour and wheat specific IgE level above 0.35 IU/L); positive oral food challenge to wheat. exclusion criteria: severe and uncontrolled asthma; chronic urticaria; significant systemic disease; poor compliance
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Daily consumption of wheat products without any complications. Timepoint: Before oral immunotherapy and 3 month after starting maintenance phase. Method of measurement: Oral food challenge with 52 gr of bread containing 5.2 g wheat protein. | — |
Secondary
| Measure | Time frame |
|---|---|
| Evaluation of skin, respiratory, gastrointestinal symptoms and anaphylaxis reaction during course of treatment. Timepoint: During buildup and maintenance phase. Method of measurement: Number of participants with adverse events and observation of their sign and symptoms. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAlireza Khayatzadeh
Department of Allergy and Clinical Immunology in Children's Medical Center at Tehran University of M
Outcome results
None listed