neoplasm of brain. Malignant neoplasm of brain (unspecified)
Conditions
Interventions
Intervention 1: 5 grams of magnesium sulfate in 1 liter of normal saline via intravenous infusion over 6 hours daily for 2 days before surgery and 5 grams of magnesium sulfate in 1 liter of normal sa
Treatment - Drugs
Placebo
5 grams of magnesium sulfate in 1 liter of normal saline via intravenous infusion over 6 hours daily for 2 days before surgery and 5 grams of magnesium sulfate in 1 liter of normal saline via intrave
Infusion of 1 liter of normal saline over 6 hours daily for 2 days before surgery and infusion of 1 liter of normal saline over 6 hours during surgery
Sponsors
Vise-Challenger of research of Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: eligible patients for brain tumor craniotomy exclusion criteria of the study: - creatinine greater than 1.5 mg / dl - Renal failure and nephrotic syndrome - Heart rate below 60 beats per minute - Severe metabolic disorders - Coagulation disorders (coagulopathy) - Myasthenia Gravis - Previous use of magnesium - Diabetes Mellitus - Age over 60 or under 18 - GCS score less than 6 - Major cardiopulmonary disease
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| CRP. Timepoint: before intervention, before surgery, after surgery. Method of measurement: ELISA kit.;S100b protein. Timepoint: before intervention, before surgery, after surgery. Method of measurement: ELISA kit. | — |
Secondary
| Measure | Time frame |
|---|---|
| Neurological adverse reactions. Timepoint: After surgery up to 6 month. Method of measurement: Clinical evaluation by neurosurgeon or neurologist.;Pain and bleeding during and after surgery. Timepoint: During and after surgery. Method of measurement: Clinical evaluation by anesthesiologist. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMohammad Reza Khajavi
Sina Hospital
Outcome results
None listed