Comparison of the efficacy of the administration of ephedrine and phenylephrine on cerebral oxygenation in patients with off-pump coronary artery bypass graft surgery candidates

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT201204154583N5

Enrollment

Registered

2014-05-04

Start date

2012-03-01

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ischemic heart disease. Other current complications following acute myocardial infarction

Interventions

Treatment - Drugs

Intervention group 1: 0.1mg/kg Ephedrine bulus dose

Intervention group 2: 2 µ/kg Ephedrine

Intervention 1: Intervention group 1: 0.1mg/kg Ephedrine bulus dose. Intervention 2: Intervention group 2: 2 µ/kg Ephedrine.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Inclusion criteria: all patients undergoing for Off-pump coronary artery bypass graft surgery. exclusion criteria: history of liver and renal diseases? history of previous neurologic disease and CVA? EF<40%

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Cerebral oxygenation. Timepoint: before and after recieving vasoconstrictor. Method of measurement: INVOS (Invos 5100 somanetic Corp, Tory, MI, usa ).;Cerebral oxygenation. Timepoint: before, during and after CX graft. Method of measurement: INVOS (Invos 5100 somanetic Corp, Tory, MI, usa ).	—

Secondary

Measure	Time frame
Mean heart rate. Timepoint: befor induction, before and after recieving first constrictor,before and after recieving second constrictor. Method of measurement: ECG.;Mean arterial blood pressure. Timepoint: befor induction, before and after recieving first constrictor,before and after recieving second constrictor. Method of measurement: sphygmometer.;Mean O2 SATURATION. Timepoint: befor induction, before and after recieving first constrictor,before and after recieving second constrictor. Method of measurement: pulse oximetery.	—

Measure

Time frame

Mean heart rate. Timepoint: befor induction, before and after recieving first constrictor,before and after recieving second constrictor. Method of measurement: ECG.;Mean arterial blood pressure. Timepoint: befor induction, before and after recieving first constrictor,before and after recieving second constrictor. Method of measurement: sphygmometer.;Mean O2 SATURATION. Timepoint: befor induction, before and after recieving first constrictor,before and after recieving second constrictor. Method of measurement: pulse oximetery.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammad Hassan Abdollahi

Shaid Sadoughi University of Medical Science

mhabdollahi@ssu.ac.ir+98 35 1525 5011

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026