Evaluation of Probiotic Efficacy in Prevention of Ventilator Associated Pneumonia

Probiotic prophylaxis to prevent ventilator-associated pneumonia in children on mechanical ventilation: A randomized double-blind clinical trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20120415009475N9

Enrollment

200

Registered

2021-05-30

Start date

2021-05-22

Completion date

Unknown

Last updated

2022-11-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ventilator-associated Pneumonia. Ventilator associated pneumonia

Interventions

Intervention 1: Intervention group: In addition to routine interventions to prevent VAP, patients will receive the Lactobacillus rutri probiotic sachet twice daily. Intervention 2: Control group: In

Eligibility

Sex/Gender

All

Age

28 Days to 12 Years

Inclusion criteria

Inclusion criteria: Age between 28 days to 12 years Children who were likely to require mechanical ventilation for more than 48 h

Exclusion criteria

Exclusion criteria: Underlying immunodeficiency Paralytic ileus Gastrointestinal bleeding

Design outcomes

Primary

Measure	Time frame
Incidence of ventilator associated pneumonia. Timepoint: 14 days after intubation. Method of measurement: Chest x-ray, Clinical sign and Lab Data.	—

Secondary

Measure	Time frame
Duration of ICU stay. Timepoint: Daily. Method of measurement: Day.;Duration of Mechanical Ventilation. Timepoint: Daily. Method of measurement: Day.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSoheil Roshanzamiri

Shahid Beheshti University of Medical Sciences

Roshanzamirisoheil@gmail.com+98 21 2222 7029

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026