comparison of the parenteral and oral Pantoprazole in children

comparison of the effectiveness of parenteral Pantoprazole with oral Pantoprazole plus bicarbonate on gastric pH in children

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20120415009475N7

Enrollment

Registered

2020-01-21

Start date

2018-09-23

Completion date

Unknown

Last updated

2020-05-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Stress ulceration prevention. Gastrointestinal mucositis (ulcerative)

Interventions

Intervention 1: Intervention group: In this group patients receive oral pantoprazole dissolved in Bicarbonate 8.4 percent solution by 1 milligram per kilogram dose every 12 hours. Intervention 2: Cont

Eligibility

Sex/Gender

All

Age

1 Months to 15 Years

Inclusion criteria

Inclusion criteria: Pediatric intensive care unit admission Mechanical ventilation Naso-gastric tube placement

Exclusion criteria

Exclusion criteria: Pantoprazole sensitivity Active gastrointestinal bleeding History of gastrointestinal ulcer

Design outcomes

Primary

Measure	Time frame
Patient's stomach pH. Timepoint: 48 hours after starting treatment. Method of measurement: By litmus paper.	—

Secondary

Measure	Time frame
Diarrhea occurrence. Timepoint: During 14 day after treatment. Method of measurement: Nurse report.;Pneumonia occurrence. Timepoint: During 14 day after treatment. Method of measurement: Based on diagnosis criteria.;Morbidity and mortality. Timepoint: Until patient discharge. Method of measurement: By report.;Stress ulcer occurrence. Timepoint: During 14 day after treatment. Method of measurement: gastric lavage.	—

Measure

Time frame

Diarrhea occurrence. Timepoint: During 14 day after treatment. Method of measurement: Nurse report.;Pneumonia occurrence. Timepoint: During 14 day after treatment. Method of measurement: Based on diagnosis criteria.;Morbidity and mortality. Timepoint: Until patient discharge. Method of measurement: By report.;Stress ulcer occurrence. Timepoint: During 14 day after treatment. Method of measurement: gastric lavage.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Bahador Mirrahimi

Shahid Beheshti University of Medical Sciences

mirrahimi@sbmu.ac.ir+98 21 2222 7020

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026