Proven or suspected Infection with methicillin resistant staphylococcus aureus candidate for Vancomycin Treatment. Methicillin resistant Staphylococcus aureus infection, unspecified site
Conditions
Interventions
Intervention 1: Intervention group: Vancomycin will be given as a loading dose of 15 mg/kg followed by a continuous infusion of 60 mg/kg over 24 hours. Intervention 2: Control group: Vancomycin will b
Sponsors
Shahid Beheshti University of Medical Sciences
Eligibility
Sex/Gender
All
Age
2 Months to 15 Years
Inclusion criteria
Inclusion criteria: Age 2 months to 15 years old Weight under 67 kg Central venous access Obtaining written consent from a legal guardian
Exclusion criteria
Exclusion criteria: Renal impairment, GFR<50 ml/min (Schwartz formula) Need for hemodialysis or CRRT Need for extracorporeal membrane oxygenation or plasmapheresis Loss of Central venous access Lysis of blood samples Discontinuation of vancomycin before 3 days of administration due to clinical judgment Retraction of consent by legal guardian
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum level of vancomycin. Timepoint: Third day of receiving vancomycin. Method of measurement: Fluorescence Polarization Immunoassays. | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical response. Timepoint: 5 Days. Method of measurement: Use the Pediatric Sequential Organ Failure Assessment score and Pediatric Risk of Mortality III score to predict mortality in the pediatric intensive care unit.;Duration of ICU stay. Timepoint: 1 Month. Method of measurement: Day. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactBaran roshan
Shahid Beheshti University of Medical Sciences
Outcome results
None listed