Patients with ulcerative colitis.
Conditions
Interventions
Intervention 1: Intervention group: Patients will receive 6 mg per kilogram of body weight per day of zataria multiflora extract for a period of 2 months along with food in three times after breakfast
Sponsors
Iran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Body mass index 18.5 to 35 kg/m2 Diagnosing ulcerative colitis by a gastroenterologist based on the Rome III Diagnostic Criteria for functional digestive disorders (flatulence, constipation and diarrhea), the Mayo score system, colonoscopy and laboratory findings Disease duration more than 6 months and less than 5 years
Exclusion criteria
Exclusion criteria: Patients with the acute phase of the disease Suffering from autoimmune diseases and other inflammatory diseases (renal, cardiovascular, liver diseases, types of cancer and acquired immunodeficiency syndrome (HIV)) Thyroid disorders History of gastrointestinal surgeries Diabetes Mellitus Pregnancy and lactation History of allergy to zataria multiflora
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| High-Sensitivity C-Reactive Protein (hs-CRP). Timepoint: Measurements at the beginning of the study (before the intervention) and 2 months after taking zataria multiflora supplement. Method of measurement: It is measured by colorimetric method and by autoanalyzer. enzyme-linked immunosorbent assay(ELISA).;Erythrocyte sedimentation rate(ESR). Timepoint: Measurements at the beginning of the study (before the intervention) and 2 months after taking zataria multiflora supplement. Method of measurement: Vacuum tube erythrocyte sedimentation rate.;Interferon gamma (IFN-?). Timepoint: Measurements at the beginning of the study (before the intervention) and 2 months after taking zataria multiflora supplement. Method of measurement: It is measured by colorimetric method and by autoanalyzer. enzyme-linked immunosorbent assay(ELISA).;Interleukin 17 (IL17). Timepoint: Measurements at the beginning of the study (before the intervention) and 2 months after taking zataria multiflora supplement. Method of measurement: It is measured by colorimetric method and by autoanalyzer. enzyme-linked immunosorbent assay(ELISA).;Total antioxidant capacity (TAC). Timepoint: Measurements at the beginning of the study (before the intervention) and 2 months after taking zataria multiflora supplement. Method of measurement: Chromatography.;Malondialdehyde (MDA). Timepoint: Measurements at the beginning of the study (before the intervention) and 2 months after taking zataria multiflora supplement. Method of measurement: Spectrophotometry.;Nuclear factor kappa light chain enhancer of activated B cells (NF-?B). Timepoint: Measurements at the beginning of the study (before the intervention) and 2 months after taking zataria multiflora supplement. Method of measurement: Real time PCR.;T-box transcription factor (T-bet). Timepoint: Measurements at the beginning of the study (before the intervention) and 2 months after taking zataria multiflora supplement. Method of measurement: Real time PCR.;GATA Bindin | — |
Secondary
| Measure | Time frame |
|---|---|
| Body Mass Index(BMI). Timepoint: Measurements at the beginning of the study (before the intervention) and 2 months after taking zataria multiflora supplement. Method of measurement: Weight in kg per square meter in height in meters.;Waist circumference. Timepoint: Measurements at the beginning of the study (before the intervention) and 2 months after taking zataria multiflora supplement. Method of measurement: The shortest distance around the waist, below the chest and above the navel.;Intensity of physical activity. Timepoint: Measurements at the beginning of the study (before the intervention) and 2 months after taking zataria multiflora supplement. Method of measurement: The amount of physical activity of individuals during the last 7 days in terms of metabolic equivalent. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Nahid Aryaeian
Iran University of Medical Sciences
Outcome results
None listed