Patients with ulcerative colitis.
Conditions
Interventions
Intervention 1: Intervention group: For 8 weeks, they will receive two capsules of 500 mg of portulaca oleracea a day, with food, twice after breakfast and dinner, which are prepared by "Perpin Elixir
Sponsors
Iran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: The patient has expressed his / her consent to participate in the study. Age 18 years and older Diagnosis of ulcerative colitis by a gastroenterologist and determination of the severity of the disease in mild to moderate stage Taking glucocorticosteroids BMI higher than 18.5 and less than 30 No pregnancy and lactation Do not take supplements (antioxidants, omega 3, etc.) in the last quarter (except for routine supplements prescribed for ulcerative colitis) No decision to become pregnant during the intervention Lack of other diseases and obvious intestinal disorders, known autoimmune diseases, cancer, inflammatory and infectious diseases No edema due to heart and kidney disease
Exclusion criteria
Exclusion criteria: Reluctance to continue cooperation No supplementation (patient acceptance and adaptation level is less than 80%). Recurrence of the disease in a way that leads to hospitalization of the patient Migration Changing the type and dose of the patient's drugs during the intervention Sudden onset of an acute illness (bacterial and viral infections, burns, heart attack, etc.) Taking anticoagulants such as warfarin or heparin Taking antihistamines and NSAIDs (ibuprofen, aspirin, diclofenac) Taking contraceptives During menstruation women
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| High-Sensitivity C-Reactive Protein (hs-CRP). Timepoint: Measurements at the beginning of the study (before the intervention) and 8 weeks after taking portulaca oleracea supplement. Method of measurement: It is calculated by calorimetric method and by autoanalyzer. enzyme-linked immunosorbent assay(ELISA).;Total antioxidant capacity (TAC). Timepoint: Measurements at the beginning of the study (before the intervention) and 8 weeks after taking portulaca oleracea supplement. Method of measurement: chromatography.;Erythrocyte sedimentation rate(ESR). Timepoint: Measurements at the beginning of the study (before the intervention) and 8 weeks after taking portulaca oleracea supplement. Method of measurement: Vacuum tube erythrocyte sedimentation rate.;Superoxide dismutase(SOD). Timepoint: Measurements at the beginning of the study (before the intervention) and 8 weeks after taking portulaca oleracea supplement. Method of measurement: Spectrophotometry.;Quality of Life. Timepoint: Measurements at the beginning of the study (before the intervention) and 8 weeks after taking portulaca oleracea supplement. Method of measurement: Questionnaire (IBDQ9). | — |
Secondary
| Measure | Time frame |
|---|---|
| Body Mass Index(BMI). Timepoint: At the beginning of the study (before the intervention) and 8 weeks after starting portulaca oleracea supplement. Method of measurement: Weight in kg per square meter in height in meters.;Waist circumference. Timepoint: At the beginning of the study (before the intervention) and 8 weeks after starting portulaca oleracea supplement. Method of measurement: The shortest distance around the waist, below the chest and above the navel.;Intensity of physical activity. Timepoint: At the beginning of the study (before the intervention) and 8 weeks after starting portulaca oleracea supplement. Method of measurement: The amount of physical activity of individuals during the last 7 days in terms of metabolic equivalent. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Nahid Aryaeian
Iran University of Medical Sciences
Outcome results
None listed