Rheumatoid Arthritis. Rheumatoid arthritis with rheumatoid factor, unspecified
Conditions
Interventions
Intervention 1: Intervention group: Receive twice a day, 2 grams of rosemary powder sachet made by Green Plants of Life Company as an additive to yogurt, buttermilk and food for 3 months. Intervention
Sponsors
Iran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Diagnosis of Rheumatoid Arthritis Based on American College of Rheumatology (ACR) Criteria (If there are at least four criteria for six weeks of the criteria 1- Morning dryness for at least one hour in three joints or more 2- Arthritis of three joint areas or more 3- Arthritis of the hand joints 4- Symmetric arthritis 5- Rheumatoid nodules 6- Positive rheumatoid factor 7- Typical radiographic changes in the wrist and hand) The patient must be over 18 years old The duration of the disease is at least one year The patient expresses his / her consent to participate in the study
Exclusion criteria
Exclusion criteria: Having any of the diseases of diabetes, hypertension, thyroid disorder and kidney failure Smoking Pregnancy and lactation Taking supplements (omega 3, antioxidants, etc.) in the last three months Taking contraceptives Changes in the amount of medication taken in the past month
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| High-Sensitivity C-Reactive Protein (hs-CRP). Timepoint: Beginning and end of the study. Method of measurement: enzyme-linked immunosorbent assay(ELISA).;Tumour necrosis factor- a(TNF-a). Timepoint: Beginning and end of the study. Method of measurement: enzyme-linked immunosorbent assay(ELISA).;Total antioxidant capacity (TAC). Timepoint: Beginning and end of the study. Method of measurement: chromatography.;Erythrocyte sedimentation rate(ESR). Timepoint: Beginning and end of the study. Method of measurement: Vacuum tube erythrocyte sedimentation rate.;Superoxide dismutase(SOD). Timepoint: Beginning and end of the study. Method of measurement: Spectrophotometry.;Tender joint counts(TJC). Timepoint: Beginning and end of the study. Method of measurement: doctor checkup.;Swollen joint count. Timepoint: Beginning and end of the study. Method of measurement: doctor checkup.;Illness severity. Timepoint: Beginning and end of the study. Method of measurement: physician global assessment.;Pain. Timepoint: Beginning and end of the study. Method of measurement: visual analogue scale.;Disease activity score. Timepoint: Beginning and end of the study. Method of measurement: Formula DAS28.;Morning stiffness. Timepoint: Beginning and end of the study. Method of measurement: How long (minutes) it takes for the joint dryness to go away. | — |
Secondary
| Measure | Time frame |
|---|---|
| Dosage of non-steroidal anti-inflammatory drugs. Timepoint: Beginning and end of the study. Method of measurement: questionnaire.;BMI. Timepoint: before intervention AND 3 months after intervention. Method of measurement: formula.;Weight. Timepoint: before intervention AND 3 months after intervention. Method of measurement: scales.;Micronutrients and Macronutrients intake. Timepoint: before intervention AND 3 months after intervention. Method of measurement: 24 hour recall questionnaire. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactNaheed Aryaeian
Iran University of Medical Sciences
Outcome results
None listed