Traumatic Brain Injury. External causes of morbidity and mortality
Conditions
Interventions
Intervention 1: Intervention arms patients will receive 400 IU/Kg Erythropoietin Alfa, intravenously, in a single dose. Intervention 2: Control group will recieve 2cc of intravenous normal saline in a
Treatment - Drugs
Placebo
Intervention arms patients will receive 400 IU/Kg Erythropoietin Alfa, intravenously, in a single dose
Control group will recieve 2cc of intravenous normal saline in a single dose
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
4 Years to 70 Years
Inclusion criteria
Inclusion criteria: Inclusion and exclusion Criteria were as follows: Patients with blunt head trauma; GCS equal or less than 13 in admission time; patient admitted in hospital less than 8 hours after trauma Exclusion Criteria: Patient’s GCS above 13 in admission time; patients with GCS=3 and pupils without reaction to light in admission time; penetrating head injury; O2-Sat bellow 90% in admission time; admission after 8 hours of injury; any critical injury in any part of the body except for head; patient with history of CPR before the intervention; any kind of severe pre-existing systemic co-morbidity; history of hypersensitivity to any injected drug; any patients with drug history of anticoagulant therapy; age under 4 years or above 70 years
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| GCS score. Timepoint: Admission time, 24 hourse. 7 days. Method of measurement: Clinical assessment (Physical examination). | — |
Secondary
| Measure | Time frame |
|---|---|
| Glasgow Outcome Scale Score. Timepoint: 6th mounth. Method of measurement: Clinical assessment (Physical examination).;Decrease in hospital stay. Timepoint: Day of discharge. Method of measurement: days. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAnowshiravan Ninezhad
Tehran university of medical sciences
Outcome results
None listed