Comparing the efficacy of morphine sulfate and oxycodone in pain management

Comparing the efficacy and adverse effects of oxycodone and morphine sulfate in isolated limb trauma patients, admitted to emergency department of Imam Khomeini hospital, between 2011 and 2012 period

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT201204089387N2

Enrollment

Registered

2013-03-26

Start date

2012-08-19

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute lower limb injury. Superficial injury of hip and thigh, Fracture of femur, Dislocation, sprain and strain of joint and ligaments of hip, Injury of muscle and tendon at hip and thigh level, Crushing injury of hip and thigh, Traumatic amputation of hip and thigh, Superficial

Interventions

5 milligrams single dose

oral

in intervention group. Intervention 2: Placebo (distilled water)

manufactured in Daroupakhsh

single dose

intravenous injection

Intervention 1: Oxycodone hydrochloride

manufactured by SOHA company

in intervention group. Intervention 3: Morphine sulfate

in control group. Intervention 4: Placebo

in control group.

Treatment - Drugs

Eligibility

Sex/Gender

All

Age

14 Years to 90 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: acute lower limb trauma Exclusion criteria: Patients younger than 14 or older than 90 years old, recent use of opioid, advanced liver/respiratory/renal diseases, head trauma, altered mental state, allergy to opioid, pregnancy

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Pain severity. Timepoint: 0, 30 and 60 minutes after administration of analgesic. Method of measurement: asking patients, using NRS score.	—

Secondary

Measure	Time frame
Side effects. Timepoint: 0, 30 and 60 minute after administration of analgesic. Method of measurement: asking patient, using questionnaire.;Blood pressure. Timepoint: Zero, 30, and 60 minutes after administration of analgesic. Method of measurement: Checking blood pressure, using appropriate cuff.;Nausea and vomiting. Timepoint: Zero, 30 and 60 minutes after administration of analgesic. Method of measurement: Asking patient, using questionnaire.;Drowsiness. Timepoint: Zero, 30 and 60 minutes after administration of analgesic. Method of measurement: Asking patient, using questionnaire.	—

Measure

Time frame

Side effects. Timepoint: 0, 30 and 60 minute after administration of analgesic. Method of measurement: asking patient, using questionnaire.;Blood pressure. Timepoint: Zero, 30, and 60 minutes after administration of analgesic. Method of measurement: Checking blood pressure, using appropriate cuff.;Nausea and vomiting. Timepoint: Zero, 30 and 60 minutes after administration of analgesic. Method of measurement: Asking patient, using questionnaire.;Drowsiness. Timepoint: Zero, 30 and 60 minutes after administration of analgesic. Method of measurement: Asking patient, using questionnaire.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammad Jalili

Tehran University of Medical Sciences

mjalili@tums.ac.ir+98 21 6641 8595

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026