Nonalcoholic steatohepatitis. Inflammatory liver disease, unspecified Hepatitis NOS
Conditions
Interventions
Intervention 1: Control group: treated with Metformin 500 mg two tablets per day plus two placebo tablet two tablets per day for six month. Intervention 2: Protexin two tablets per day plus Metformin
Behavior
Treatment - Drugs
Control group: treated with Metformin 500 mg two tablets per day plus two placebo tablet two tablets per day for six month
Protexin two tablets per day plus Metformin 500 mg two tablets per day for six month
Sponsors
Isfahan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: patients admitted to Al Zahra hospital over 18 years, who have NASH confirmed by biopsy. Exclusion criteria: any participant who will take antibiotics for any indication for more than 1 week during the study period or before recruitment to the study; loosing more than 10% of baseline body weight during the study period; autoimmune hepatitis; Wilson's disease; HBV/HCV/HIV/EBV/CMV infection; pregnancy and lactation
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Alanine transaminase (ALT). Timepoint: Before and after treatment. Method of measurement: Blood test.;Aspartate aminotransferse (AST). Timepoint: before and after treatment. Method of measurement: blood test AST.;Ultrasound Grade of NASH. Timepoint: before and after treatment. Method of measurement: ultrasound. | — |
Secondary
| Measure | Time frame |
|---|---|
| Fasting blood suger (FBS). Timepoint: before and after treatment. Method of measurement: blood test.;Chlosterol. Timepoint: befoer and after treatment. Method of measurement: blood test.;Triglyceride. Timepoint: before and after treatment. Method of measurement: blood test.;Body mass index (BMI). Timepoint: before and after treatment. Method of measurement: measure weight and height. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactHassan Firouzian
Isfahan University of Medical Sciences
Outcome results
None listed