Autism. Pervasive developmental disorders
Conditions
Interventions
Intervention 1: Risperidone with gradual increasing in dose will be prescribed as bellow: 0.02mg/kg/day at begining, 0.04 mg/kg/day at second week and ultimately will be increased to 0.06 mg/kg/day at
Treatment - Drugs
Risperidone with gradual increasing in dose will be prescribed as bellow: 0.02mg/kg/day at begining, 0.04 mg/kg/day at second week and ultimately will be increased to 0.06 mg/kg/day at third week. Cal
Memantine with gradual increasing in dose will be prescribed as bellow: 0.2mg/kg/day at begining, 0.3mg/kg/day at second week and ultimately will be rised to 0.4mg/kg/day at third week. Calculated dos
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
4 Years to 17 Years
Inclusion criteria
Inclusion criteria: inclusion criteria: age of 4-17 year old; autistic patients not received any drug for treatment in past or not responded adequately to previous drugs; seizure attacks in epileptic patients should be controlled and any change in dose and kind of antiepileptic drugs should not be made from one month before entrance to the study. exclusion criteria: any neurologic disease except for seizure; substance abuse; pregnancy; any history of neuroleptic malignant syndrom and history of allergic reactions to mementine or risperidone; history of cardiovascular diseases, malignant hematologic diseases, acute kidney or liver failure.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Autism symptoms. Timepoint: before intervention, four and eight weeks after intervention. Method of measurement: Aberrant Behavioral Check list and Childhood Autism Rating Scale scales. | — |
Secondary
| Measure | Time frame |
|---|---|
| Side effects including any side effect that related to the drug. Timepoint: two, four and eight weeks after intervention. Method of measurement: side effects checklist. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactNaemeh Nikvarz
Tehran University of Medical Sciences
Outcome results
None listed