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Effects of progesterone on uterine vascular flow in pregnant women

Evaluation of progesterone administration effects on uterine vascular flow in pregnant women with intrauterine growth restriction fetus and preterm labor

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT201203289338N1
Enrollment
100
Registered
2012-06-14
Start date
2012-08-22
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Preterm labor and IUGR Fetus. Slow fetal growth, unspecified

Interventions

Intervention 1: In preterm labor group, 40 mg vaginal progesterone is administered daily within 2 weeks and Doppler sonography parameters were assessed before and after administration. Intervention 2:
Treatment - Drugs
In preterm labor group, 40 mg vaginal progesterone is administered daily within 2 weeks and Doppler sonography parameters were assessed before and after administration
In IUGR group, 40 mg vaginal progesterone is administered daily within 2 weeks and Doppler sonography parameters were assessed before and after administration

Sponsors

Tehran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
15 Years to 50 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Pregnant women between 24 and 37 weeks of pregnancy; diagnosis of Intrauterin growth restriction or preterm labor; receiving progesterone between 24 to 48 hours after administration of tocolytics Exclusion Criteria: Concomitant administration of progesterone and tocolytics; administration of progesterone in previous pregnancy; labor within upcoming 2 weeks; multiple gestations

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
S/D Umbilical Artery. Timepoint: 1st and 14th days. Method of measurement: Color Doppler Sonography.;PI in middle cerebral artery. Timepoint: 1st and 14th days. Method of measurement: Color Doppler Sonography.;RI in Uterine Artery. Timepoint: 1st and 14th days. Method of measurement: Color Doppler Sonography.;PI in middle cerebral artery. Timepoint: 1st and 14th days. Method of measurement: Color Doppler Sonography.;PSV in MCA. Timepoint: 1st and 14th days. Method of measurement: Color Doppler Sonography.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMahnaz Jahani

Tehran University of Medical Sciences

m-jahani@razi.tums.ac.ir dr.jahani33@yahoo.com+98 21 6119 2382

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026