Acne Vulgaris. Acne
Conditions
Interventions
Interventional group:receiving solid lipid nanoparticles (SLNs) containing 0.05% isotretinoin once a day for 8 weeks.
Intervention 1: Control group: receiving of 0.05% isotretinoin gel ( isotrex)
made in Irland. once a day for 8 weeks. Intervention 2: Interventional group:receiving solid lipid nanoparticles (SLNs) containing 0.05% isotretinoin once a day for 8 weeks.
Treatment - Drugs
Control group: receiving of 0.05% isotretinoin gel ( isotrex)
made in Irland. once a day for 8 weeks
Sponsors
Nano Technology Research Center,Mashhad University of Medical Sciences
Eligibility
Sex/Gender
All
Age
13 Years to 30 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria:Acne vulgaris patients with grade 2 and 3 base on Investigator Global Assessment; No receiving topical treatment of acne from 4 weeks before this regimen. exclusion criteria:Androgenic acne;Acne due to drugs or cosmetics; Adrenal or Hormonal disorders.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Inflammatory and non-inflamatory lesions. Timepoint: Biweekly after starting treatment. Method of measurement: Observation and calculating of elementary lesions based on photographic image. | — |
Secondary
| Measure | Time frame |
|---|---|
| Evaluation of side effects like skin irritation , erythema , skin dryness.pruritus. Timepoint: Biweekly. Method of measurement: Observation and severity scoring from + to +++. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDanial Bagheri
Nano Technology Research Center and faculty of pharmacy
Outcome results
None listed