Effectiveness of 20 mg Doxycycline on periodontal therapy

Effectiveness of adjunctive Subantimicrobial Dose Doxycycline on phase I of periodontal therapy

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT201203229321N1

Enrollment

Registered

2012-04-11

Start date

2011-12-07

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic periodontitis. Chronic periodontitis

Interventions

Intervention 1: Scaling and 20 mg Doxycycline b.i.d for 3 months. Intervention 2: Scaling and placebo (starch, 20mg, b.id) for 3 months.

Treatment - Drugs

Placebo

Scaling and 20 mg Doxycycline b.i.d for 3 months.

Scaling and placebo (starch, 20mg, b.id) for 3 months.

Eligibility

Sex/Gender

All

Age

26 Years to 70 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Patients with at least 14 teeth, 8 pocket with PD =5 mm and CAL =4 mm. Exclusion criteria: patients with systemic disease or hyper sensitivity to any antibiotic from tetracycline family; usage of antibiotic or any other drugs and periodontal therapy in 4 last months; usage of alcohol or smoking; pregnancy and lactation.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Pocket depth. Timepoint: Base line, 3 and 6 months later. Method of measurement: Williams probe (mm).;Clinical attachment loss. Timepoint: Base line, 3 and 6 months later. Method of measurement: Williams probe (mm).;Bleeding on probing. Timepoint: Base line, 3 and 6 months later. Method of measurement: Williams probe (mm).	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Ahmad Haerian

Dental School, Shahid Sadoughi University of Medical Sciences

ahmad.haerian@ssu.ac.ir+98 36 1621 4257

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026