Ischemic stroke. Cerebral infarction
Conditions
Interventions
Intervention 1: Citalopram tablets(produced with commercial name? as Citalopram product by Sobhan Pharma Co.)/ 20 mg Daily. Intervention 2: Placebo as the same shape and size and color as Citalopram t
Treatment - Drugs
Placebo
Citalopram tablets(produced with commercial name? as Citalopram product by Sobhan Pharma Co.)/ 20 mg Daily
Placebo as the same shape and size and color as Citalopram tablets
Sponsors
Neurosciences Research Center
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: 1- Acute ischemic stroke hospitalization in Razi university hospital; 2- No previous use of citalopram and other antidepressants, MAOI, Neuroleptic drugs and benzodiazepines in the last month before the onset of symptoms; 3- Not having a severe disability after stroke(NIHSS18). Exclusion criteria: 1- Request of patients to Exit from the study; 2- Previous chronic disease interferes with the performance evaluation in patients such as: chronic infections, liver or kidney failure, cancers; 3- Residual weakness of previous stroke; 4- Pregnancy or breastfeeding or any conditions that makes follow up impossible; 5- Sever loss of Consciousness; 6- Thrombolytic therapy; 7-Endarterectomy; 8- Depression(MADRS>18).
Exclusion criteria
Exclusion criteria:
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Prognosis after stroke. Timepoint: At hospitalization(0), discharge(1), and after 3 months(2). Method of measurement: Modifi ed Rankin scale (MRS). | — |
Primary
| Measure | Time frame |
|---|---|
| Functional status after stroke. Timepoint: At hospitalization(0), discharge(1), and after 3 months(2). Method of measurement: Functional status score based on NIHSS(National institutes of health stroke scale)(at least 50% reduction in NIHSS score in 3-month compared to the baseline score. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Ehsan Sharifipour
Tabriz University of Medical Sciences
Outcome results
None listed